ERKEN EVRE MİKOZİS FUNGOİDES’DE NÖTROFİL/LENFOSİT ORANI, TROMBOSİT/LENFOSİT ORANI VE ORTALAMA TROMBOSİT HACMİNİN PROGNOSTİK ÖNEMİ

Amaç: Mikozis Fungoides (MF), primer kutan T hücreli lenfomalar arasında en sık görülen lenfomadır. Erken evrelerde tanı alan birçok hastada prognoz oldukça iyi olmasına rağmen, bazı hastalarda hızla ileri evrelere geçiş görülebilmektedir. Son zamanlarda nötrofil/lenfosit oranı (NLO), trombosit/lenfosit oranı (TLO) ve ortalama trombosit hacmi (OTH) lenfomalarda prognostik belirteç olarak kullanılmakla birlikte, literatürde MF’li hastalarda bu konuda veri bulunmamaktadır. Gereç ve Yöntem: Dokuz Eylül Üniversitesi Tıp Fakültesi Deri ve Zührevi Hastalıklar Anabilim Dalı’nda erken evre MF tanısı koyulan ve en az 5 yıllık izlemi olan olguların verileri retrospektif olarak taranmıştır.Bulgular: Çalışmaya dâhil edilen 67 olgunun 15 (%22,4)’inde, hastalığın ileri evrelere geçiş gösterdiği belirlenmiştir. Vücut yüzey alanında ≥%10 tutulum, lenfopeni varlığı ve artmış NLO (>2,60) ve TLO’nun (>138,3) kötü prognoz ile ilişkili olduğu, NLO’nun ise bağımsız bir prognostik belirteç olduğu saptanmıştır. Sonuç: NLO ve TLO, MF’de erken evrelerdeki yüksek riskli hastaları belirlemek amacıyla kullanılabilecek kolay ve ucuz bir tarama yöntemi olabilir.

Anahtar Kelimeler:

nötrofil, lenfosit, trombosit, trombosit hacmi

Prognostic significance of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and mean platelet volume in the early stage mycosis fungoides

Objective: Mycosis Fungoides (MF) is the most common lymphoma among the primary cutaneous T-cell lymphomas. Although the prognosis is excellent in many patients diagnosed in the early stages, rapid transition to advanced stages may be seen in some patients. Recently, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) have been used as prognostic markers in lymphomas; however, there is no existing data in literature in patients with MF. Material and Method: The data of patients diagnosed with early stage MF having at least a 5-year follow up in the Skin and Venereal Diseases Department of Dokuz Eylul University Faculty of Medicine were retrospectively reviewed. Results: Transition to the advanced stages of the disease were observed in 15 (22.4%) of the 67 cases included in the study. The involvement ≥10% of the body surface area, presence of lymphopenia, and increased NLR (>2.60) and PLR (>138.3) were associated with poor prognosis, and NLR was found to be an independent prognostic marker. Conclusion: NLR and PLR may prove to be a simple and low cost screening method to identify high-risk patients in early stages of MF.

Keywords:

Neutrophil, lymphocyte, platelet, platelet volume,

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