Levent URTEKİN, Hicabi SEZGİN, Ali SEVİM, Nuran AY

Ti İmplantların Biyofilim Engelleme Amaçlı Nano hBN - HA ile Kaplanmasının Yüzey Karaktersitiğine Etkisinin Belirlenmesi

Birçok metal alaşımı implant uygulamalarında geniş bir şekilde kullanılmaktadır. Bu metal alaşım yüzeylerine kolonize olan bakteriler implanta bağlı olarak enfeksiyon oluşturabilmektedir. Bu çalışmada implant yüzeyine hidroksiapatit ve nano hexogonal bornitrür ile kaplama yapılarak biyofilim ve buna bağlı enfeksiyon oluşumunu engellemek amaçlı yüzey karakteristiği tayin edilmiştir. Kaplama sonrası yüzeyde oluşan pürüzlülük değişimi, sertlik değişimi ve SEM analizleri gerçekleştirilmiştir. Elde edilen biyo-yüzeyin Staphylococcus aureus bakterisine olan ilgisi araştırılmaya devam etmektedir.

Anahtar Kelimeler:

Biyofilm, Kaplama, Implant, Ti alaşım

PDF

___

Amoroso PF, Adams RJ, Waters MG, Williams DW., 2006, Titanium surface modification and its effect on the adherence of Porphyromonas gingivalis: an in vitro study. Clin Oral Implants Res., vol. 17:6 pp. 633.
Badihi Hauslich L, Sela MN, Steinberg D, Rosen G, Kohavi D., 2011, The adhesion of oral bacteria to modified titanium surfaces: role of plasma proteins and electrostatic forces. Clin Oral Implants Res., Dec 13.
Baıley P. J., Cousıns G., Snow, G. A. , Whıte A. J. , 1980, Boron-Containing Antibacterial Agents: Effects on Growth and Morphology of Bacteria Under Various Culture Conditions. Antımıcrobıl Agents And Chemotherapy, Apr. pp. 549.
Besra L., Liu M., 2007, A review on fundamentals and applications of electrophoretic deposition (EPD), Prog. Mater. Sci. vol. 52 pp. 1.
Boccaccini A.R., Keim S., Ma R., Li, Y., Zhitomirsky I., 2010, Electrophoretic deposition of biomaterials, J. R. Soc. Interface, vol. 7 pp. 581.
Bosco R., Van Den Beucken J., Leeuwenburgh S., Jansen J., 2012, Surface engineering for bone implants: a trend from passive to active surfaces, Coatings vol. 2 pp. 95.
Farnoush H., Aldıç G., Çimenoğlu H., 2015 Functionally graded HA–TiO2 nanostructured composite coating on Ti–6Al–4V substrate via electrophoretic deposition, Surf. Coat. Technol., vol. 265 pp. 7.
Göncü Y., Geçgin M., Bakan F., Ay N., 2017, Electrophoretic deposition of hydroxyapatite-hexagonal boron nitride composite coatings on Ti substrate, Materials Science and Engineering: C, vol.79 pp. 273.
Iqbal N., Nazir R., Asif, A., Chaudhry A.A., Akram M., Fan G.Y., Akram A., Amin R., Park S.H., Hussain R., 2012, Electrophoretic deposition of PVA coated hydroxyapatite on 316L stainless steel, Curr. Appl. Phys., vol. 12 pp. 755.
Javidi M., Javadpour S., Bahrololoom M.E., Ma,J., 2008, Electrophoretic deposition of natural hydroxyapatite on medical grade 316L stainless steel, Mater. Sci. Eng. C Biomim. Supramol. Syst. vol. 28 pp. 1509.
Kim H.W., Koh, Y.H., Li L.H., Lee S., Kim H.E., 2004, Hydroxyapatite coating on titanium substrate with titania buffer layer processed by sol–gel method, Biomaterials, vol. 25 pp. 2533.
Lahiri D., Ghosh S., Agarwal A., 2012, Carbon nanotube reinforced hydroxyapatite composite for orthopedic application: a review, Mater. Sci. Eng. C, vol. 32 pp. 1727.
Lin C., Han H., Zhang F., Li A., 2008, Electrophoretic deposition of HA/MWNTs composite coating for biomaterial applications, J. Mater. Sci.Mater. Med. vol. 19 pp. 2569.
Mahmoodi S., Sorkhi L., Farrokhi-Rad M., Shahrabi T.,2013, Electrophoretic deposition of hydroxyapatite-chitosan nanocomposite coatings in different alcohols, Surf. Coat.Technol., vol. 216 pp. 106.
Mohseni E., Zalnezhad E., Bushroa A., 2014, Comparative investigation on the adhesion of hydroxyapatite coating on Ti–6Al–4V implant: a review paper, Int. J. Adhes. Adhes. vol.48 pp. 238.
Narayanan R., Seshadri S.K., Kwon T.Y., Kim K.H. 2008, Calcium phosphate-based coatings on titanium and its alloys, J. Biomed. Mater. Res. B Appl. Biomater. vol. 85B pp. 279.
Pang X., Zhitomirsky I., 2008, Electrodeposition of hydroxyapatite-silver-chitosan nanocomposite coatings, Surf. Coat. Technol., vol. 202 pp. 3815.
Parente P., Sanchez-Herencia A.J., Mesa-Galan M.J., Ferrari B., 2013, Functionalizing Ti-surfaces through the EPD of hydroxyapatite/NanoY2O3, J. Phys. Chem., vol. 117 pp. 1600.
Quirynen M. , Van Der Mei HC. , Bollen CM., at al., 1993, An in vivo study of the influence of the surface roughness of implants on the microbiology of supra- and subgingival plaque. J Dent Res., vol. 72:9 pp. 1304.
Ribeiro M. , Monteiro F.J., Ferraz M.P., 2012, Infection of orthopedic implants with emphasis on bacterial adhesion process and techniques used in studying bacterial-material interactions. Biomatter. Oct 1; vol. 2(4): pp. 176.
Sayin Z, Ucan US, Sakmanoglu A., 2016, Antibacterial and Antibiofilm Effects of Boron on Different Bacteria. Biol Trace Elem Res. vol. 173(1) pp. 241.
Shojaee P., Afshar A., 2015, Effects of zirconia content on characteristics and corrosion behaviorof hydroxyapatite/ZrO2 biocomposite coatings codeposited by electrodeposition, Surf. Coat. Technol., vol. 262 pp. 166.
Yeo I. , Kim HY. , LimKS. , Han JS , 2012, Implant surface factors and bacterial adhesion: a review of the literature. Int J Artif Organs., vol. 35:10 pp. 762.
Zhou-Cheng W., Yong-Jin N., Jin-Cong H., 2008, Fabrication and Characterization of HAp/Al2O3 Composite Coating on Titanium Substrate, Bioinformatics and Biomedical Engineering, ICBBE The 2nd International Conference on, 20081526–1530.