Tüberküloz menenjitli çocuklarda kranial tomografi ve kranial magnetik rezonans bulgularının irdelenmesi
Tüberküloz menenjit; erken tedavisi yapılmadığı takdirde %50-70’lere varan mortaliteye sahiptir.Çalışmaya; Dicle Üniversitesi Çocuk Hastalıkları Kliniği’nde 2000-2003 yılları arasında takip edilen 5 ay-15 yaş arası 142 hasta alındı. 91(%64) erkek, 51(%36) kız idi. Kliniğe başvurudan sonraki ilk üç günde kranial tomografi, ilk on gün içinde kranial magnetik rezonans çekilmiştir. Kranial tomografi çekilmiş (134/142) hastalarda en sık % 91.7 hidrosefali, sonra 14 hastada (%10,4) serebral enfarkt ve beyin ödemi, 13 hastada (%9.7) meningeal ve parankimal tutulum, 11 hastada (%8.2) basal sisternada tutulum, sekiz hastada (%5.9) serebral atrofi , yedi hastada (%5.2) tüberkülom ve son olarak da üç (%2.2) hastada sonuç normal bulundu. Kranial magnetik rezonans çekilmiş (33/142) hastalarımızda en sık %75.7 hidrosefali, sonra %48.4 meningeal ve parankimal tutulum, %45.4 basal sisternada tutulum, %30.2 serebral enfarkt, %15.1 tüberkülom ve %6.0 hastada serebral atrofi olduğu görüldü. Klinik ve anormal BOS bulguları ile tüberküloz menenjit düşünülen hastalarda erken tanı ve tedavi için, erken dönemde bir kranial görüntülemenin yararlı olacağını düşünüyoruz.
The evaluation of cranial tomographical and magnetic resonans image findings otomografiain from the children with tuberculous meningitis
Mortality rate in tuberculous meningitis may reach from 50 % to 70 % if not treated at early stages.This study consists of 142 patients admitted Dicle University of Pediatrics clinic and who were examined regularly in the clinic. Of these patients, 91 (64%) were male and 51(36%) female. Patient ages ranged between five months and 15 years old. Cranial tomographies images of patients were obtained within the first three days and cranial magnetic resonance imaging were obtained within the first ten days of admittance.Cranial tomography findings include hydrocephalus in 134 (134/142) patients(91.7%), cerebral infarct and brain edema in 14 patients (10.4%), meningeal and paranchimal involvement in 13 patients (9.7%), basal cisterna involvement in 11 patients(8.2 %), cerebral atrophy in eight patients (5.9 %) and tuberculoma in seven patients (5.2%), Three patients (2.2 %) were to be found normal. Cranial magnetic resonance imaging otomografiained from 33 patients (most common findings) determined hydrocephalus in 75.7 % of the patients. Meningeal and paranchimal involvement in 48.4 %, basal cisterna involvement in 45.4 %, cerebral infarct in 30.2 %, tuberculoma in 15.1 %, cerebral atrophy in 6.0 % percent of the patients were determined respectively. In conclusion, we believe that in the early stage of the disease otomografiaining cranial imaging in suspected tuberculous meningitis with clinical and abnormal cerebrospinal fluid findings for early diagnosis and treatment should be beneficial.
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- 1. World Health Organization. TB: a global emergency. Geneva, World Health Organization 1994;94-179
- 2. Türkiye’de verem hastalığının seyri üzerine bir araştırma. Sağlık Bakanlığı Verem Savaş Daire Başkanlığı, Ankara 1984
- 3. Garg RK. Tubercukosis of the central nevrous system. Postgrad Med J 1999;75:133-140
- 4. Garcia-Monco JC. Central nervous system tuberculosis. Neurologic Clinics 1999;17:737-755
- 5. Contwell M, Shebab Z, Costello A et all. Epidemiology of tuberculosis in the United States, 1985 through 1992, Jama 1994; 272:535-539
- 6. Rudolph CD, Rudolph AM, Hastetter MK, Lister G, Jiens NJ. Rudolph’s Pediatrics 21. ed chapter 13
- 7. Mc Millan JA, DeAngelis CD, Feigin RD, Warshaw JB. Oskis Pediatrics third ed 1999;185:1032-1033
- 8. Göçmen A. BCG aşısı Katkı Pediatri Dergisi 1994;15:1-2
- 9. BCG vaccination in tuberculosis control:a manuel on methods and procedures for integrated programs. Pan American Health Organisation Wishinston WHO Scientific Publication 1986;498:10-20
- 10. Katz SL, Gershon AA, Hotez PJ. Krugman’s infectious diseases of children. 10th ed. St Louis: Mosby-Year Book Inc 1998;35:571-600.
- 11.Behrman RE, Kliegman RM, Arvin AM. Nelson Textbook of Pediatrics. 16th ed. Philadelphia, W.B. Saunders Comp, 2000;12:683-689.
- 12.Neyzi O, Ertuğrul T. Pediatri 3. Baskı Nobel Tıp Kitabevleri. İstanbul 2002;9;526-531
- 13. Doer CA, Starke JR and Ong LT. Clinical and public health aspects of tuberculous menengitis in children. J Pediatr 1995;127:27-33
- 14.Trautmann M, Kluge W, Otto HS, Loddenkomper R. Computed tomography in CNS tuberculosis. Eur Neurol 1986;25:91-97
- 15. Altunbaşak Ş, Alhan E, Baytok V, et all. Tuberculous meningitis in children. Acta Pediatrica Japonica 1994; 36: 480-84
- 16. Yaramış A, Gürkan F, Elevli, et all. Central nervous system tuberculosis in children: a review of 214 cases. Pediatrics 1998; 102
- 17. Upadhyaya P, Bhargava S, Sundaram KR et all. Hydrocephalus caused by tuberculosis meningitis: Clinical Picture, CT findings and results of shunt surgery. Z Kinderchir 1983;38:76-79
- 18. Özateş M, Kemaloğlu S, Gürkan F, et all. CT of brain in tuberculosis meningitis: A review of 289 patient. Acta Radiol 2000;41:13-17
- 19. Waecker NJ and Connor JD. Central nervous system tuberculosis in children: a review of 30 cases. Pediatr Infect Dis J, 1999;9:539-43
- 20. Shian WJ, Chi CS. Central nervous system tuberculosis in infants and children. Zhonghua Yi Xue Ze Zhi (Taipes) 1993;52:391-97
- 21. Kumar R, Kohli N, Thavnani H, et all. Value CT scan in diagnosis of meningitis. İndian Pediatr 1996;36: 465-68
- 22. Uysal G, Köse G, Güven A, Diren B. Magnetic resonance imaging in diagnosis of central nervous system tuberculosis. İnfection 2000; 29:148-153
- 23. Chang KH, Han MH, Roh JK, Kim IO et all. Gd-DTPA enhanced MR imaging in intracranial tuberculosis. Neuroradiology 1990; 32:19-25
- 24. Schoeman J, Hewlet R and Donald P. MR of childhood tuberculous meningitis. Neuroradiology 1988;30:473-47