Çocukluk çağında viral enfeksiyon lösemi birlikteliği: İki olgu sunumu

Hepatit A ve kızamık enfeksiyonu çocukluk yaş grubunda sık görülen viral enfeksiyonlardandır. Akut lösemiler gibi immunosüpresif hastalarda viral infeksiyonlar ciddi sorunlar yaratabilir. Bazı viral enfeksiyonların hematolojik malignensi potansiyelleri bilinmektedir. Bu makalede ilk tanı anında viral hepatit A enfeksiyonu ile başvuran batında asit ve plevral effüzyonu olan bir akut lenfoblastik lösemi (ALL) olgusu ile kızamık enfeksiyonu ile başvuran bir ALL olgusu sunulmaktadır. Bu olgular ile viral infeksiyonların lösemiye neden olabileceği veya viral enfeksiyonların lösemiyle birlikte görülebileceği tartışılacaktır.

Anahtar Kelimeler:

Hepatit, viral, insan, Virüs hastalıkları, Çocuk, Çocuk, okul öncesi, Kadın, Hepatit A, Lösemi, Kızamık

The association of viral infection and acute leukemia in childhood: Two cases reports

Hepatitis A and Measles are the most common viral infection in pediatric patients. Viral infections causes to serious problem in immunocompromised patients such as acute leukemias. It is known that some viral infection agent causes hematologic malignancies. We report here two patient with acute leukemias who admitted to our clinic with similar to viral infection. The first case is a patient with acute lymphoblastic leukemia (ALL) presented with ascites and pleural effusion. In this patient, the major clinical problem is hepatitis A. The second case is a patient with ALL who admitted with symptoms of measles. We discussed here, some viral infections may cause to leukemia and those may be associated with leukemias

Keywords:

Hepatitis, Viral, Human, Virus Diseases, Child, Child, Preschool, Female, Hepatitis A, Leukemia, Measles,

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1. Henderson BE. Establishment of an association between a virus and a human cancer. J Natl Cancer Inst, 1989 ;81:320-1.
2. McNally RJ, Eden TO. An infectious aetiology for childhood acute leukaemia: a review of the evidence. Br J Haematol, 2004;127:243-63.
3. Simonian N, Janner D. Pleural effusion, hepatitis and hemolytic anemia in a twelveyear- old male child. Pediatr Infect Dis J, 1998; 17: 173-174.
4. Dagan R, Yagupsky P, Barki Y. Acute ascites accompanying hepatitis A infection a child. Infection, 1988;16:360-361.
5. Cohen HA, Amir J, Frydman M, Gross S, Hart J, Ziv JB. Infection with the hepatitis A virus associated with ascites in children. Am J Dis Child, 1992; 146: 1014-1016.
6. Simmons WW, Warren RE. Eosinophilic pleural effusion associated with recovery from viral hepatitis A. J Clin Gastroenterol, 1994:19;143-145.
7. Gürkan F. Ascites and pleural effusion accompanying hepatitis A infection in a child. Clin Microbiol Infect, 2000;5:286-287.
8. Zur Hausen H. Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers. Cancer Res, 1989 ; 49:4677-81.
9. Shapiro RS, McClain K, Frizzera G, Gajl-Peczalska KJ, Kersey JH, Blazar BR, et al. Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation. Blood, 1988;71:1234-43.
10. Arthur MJ, Hall AJ, Wright R. Hepatitis B, hepatocellular carcinoma, and strategies for prevention. Lancet, 1984 ;1:607-10.
11. Kinlen LJ. Epidemiological evidence for an infective basis in childhood leukaemia. Br J Cancer, 1995 ;71:1-5.
12. Koushik A, King WD, McLaughlin JR. An ecologic study of childhood leukemia and population mixing in Ontario, Canada. Cancer Causes Control. 2001 ;12:483-90.
13. Greaves MF. Aetiology of acute leukaemia. Lancet, 1997 ;349:344-9.
14. Smith M. Considerations on a possible viral etiology for B-precursor acute lymphoblastic leukemia of childhood. J Immunother, 1997 ; 20: 89-100.
15. Haimi M, Ben-Arush MW, Kassis I, Postovsky S, Kra-Oz Z, Elhasid R. Bullous herpes zoster in a child with leukemia: case report and review of the literature. J Pediatr Hematol Oncol, 2004 ; 26:587-90.