Tip 1 diyabetli hastalarda açlık, tokluk kan şekerleri ile HbA1c arasındaki ilişki

Açlık ve tokluk kan şekerleriyle HbA1c ilişkisi birçok çalışmada araştırılmıştır. Bu çalışmada tip 1 diyabetli hastalarda açlık kan şekeri (AKŞ), tokluk kan şekeri (TKŞ) ve HbA1c arasındaki ilişkiyi araştırdık. Polikliniğimize başvuran tip 1 diyabetli 86 hasta çalışmaya alındı. Hastaların AKŞ, TKŞ ve HbA1c düzeylerine bakıldı. Değişkenler arasında Pearson korelasyonu uygulandı. Hastaların yaş ortalaması 26,8±8,4 yıl ve diyabet süreleri 6,9±4,2 yıl hesaplandı. Hastaların AKŞ, TKŞ ve HbA1c ortalamaları sırasıyla 230±109 mg/dl, 299±123 mg/dl ve 9,8±2,8% bulundu. 13 hastanın (%15,1) HbA1c değeri %7 değerinin altındaydı. AKŞ ve TKŞ değerlerinin HbA1c ile korelasyonu sırasıyla r=0,26 (p

The relationship between fasting, postprandial glucose levels and HbA1c in patients with type 1 diabetes

Several previous studies investigated the relationship between plasma glucose and HbA1c. We aimed to evaluate the relationship between HbA(1c) and fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) levels in type 1 diabetic subjects 86 Type 1 diabetic patients admitted to our department were included. FPG, PPG and HbA1c values were recorded. Pearson&#8217;s correlation was used between FPG, PPG and HbA1c. The mean age was 26.8±8.4 years, and mean duration of diabetes was 6.9±4.2 years. The means of FPG, PPG, and HbA1c were 230±109 mg/dl, 299±123 mg/dl ve 9,8±2,8%, respectively. A HbA1c level < 7.0% was obtained in 13 (15.1%) patients. Pearson's correlation coefficient for HbA1c and FPG, and PPG 0.26 (p<0,05), and 0.46 (P<0.01), respectively. Correlation was higher in males. The correlation coefficient of patients with type 1 diabetes for HbA1c and PPG is lower than those of HbA1c and FPG. Therefore, we suggest that using PPG in diabetes management.

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  • 1. Rahbar S, Blumenfield O, Ranney HM. Studies on an unusual hemoglobin in patients with diabetes mellitus. Biochem Biophys Res Commun 1969;36; 838-843.
  • 2. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Eng J Med 1993; 329: 977-986.
  • 3. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood glucose control with sulphonyureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-853.
  • 4. American Diabetes Assosiation. Postprandial blood glucose(Consensus Statetment). Diabetes Care 2001;24: 775-778.
  • 5. Ozmen S, Cil T, Atay AE, Tuzcu AK, Bahceci M. A simple way to estimate mean plasma glucose and to identify Type 2 diabetic subjects with poor glycaemic control when a standardized HbA(1c) assay is not available. Diabet Med. 2006; 23:1151-1154
  • 6. Salardi S, Zucchini S, Santoni R, Ragni L, Gualandi S. The glucose area under the profiles obtained with continuous glucose monitoring system relationships with HbA1c in pediatric Type1 diabetic patients. Diabetes Care 2002: 25; 1840-1844
  • 7. Landgraf Rüdiger. The relationship of postprandial glucose to HbA1c. Diabetes metabolism research and reviews 2004; 20:9-12
  • 8. Hillman N, Herranz L, Grande C, Vaquero P.M, Pallardo L.F. What is the relative contribution of blood glucose levels at different time points of the day to HbA1c in Type1 diabetes? Doi: 10.1111/j. 1464-5491. 2004.01184