EMEL TORUN, Ergül CİNDEMİR, İLKER TOLGA ÖZGEN, Faruk ÖKTEM

Subclinical hypothyroidism in obese children

Amaç: Çocukluk çağı obezitesinde tiroid fonksiyonlarının değerlendirilmesi, subklinik-klinik hipotiroidinin saptan- ması amaçlanmıştır.Gereç ve yöntem: Çalışmamızda, 2-18 yaş arasında 85 obez (Vücut kitle indeksi >97. persentil), 47 obez olmayan hastanın, serbest triiyodotironin (sT3) ve tiroksin (sT4) ve tiroid stimülan hormon (TSH) düzeylerine bakıldı. Obez grupta, TSH düzeyi 5,4 IU/ml’nin üzerinde saptanan has- taların, tiroid otoantikor düzeyleri ölçüldü ve tiroid ultraso- nu yapılarak tiroid vo-lümü hesaplandı.Bulgular: Obez hastaların sT3 ortalamaları ve TSH de- ğerleri, kontrol grubunun değerlerinde istatistiksel olarak anlamlı derecede yüksek bulunurken (P=0,001), sT4 orta- lamalarında iki grup arasında fark saptanmadı. TSH >5,4 IU/ml olan hastalardan birinde otoantikor düzeylerinde yükseklik saptandı. TSH >5,4 IU/ml olan 28 hastadan 25’inin tiroid ultrasonu normal iken, kalan 3 hastada tiroi- dit veya nodül saptandı ancak tiroid büyümesi yoktu. Sonuç: Obez çocuklarda sT3 ve TSH düzeyi obez olma- yanlara kıyasla yüksek, sT4 ise normal bulundu.

Obez çocuklarda subklinik hipotiroidi

Objective: Thyroid functions in obese children and ado- lescents were evaluated in order to determine subclinical and clinical hypothyroidism. Materials and methods: In this study, 85 obese (Body mass index >97th percentile) children, aged 2-14 years, as well as 47 healthy controls were enrolled. Levels of serum free triiodothyronine (fT3), free thyroxine (fT4) and thyroid- stimulating hormone (TSH) of the two groups were com- pared. Obese children with TSH level above 5.4 IU/ml were also analyzed for thyroid autoantibodies and thyroid ultrasounds were performed. Results: Obese children showed higher serum concen- trations of TSH and fT3 than the controls but no significant difference in serum fT4 levels was found between the two groups (P=0.001). One child had high auto antibodies and 32 had high TSH levels. Of 28 children with TSH >5,4 IU/ml, 25 children had normal thyroid ultrasound findings and three had nodules or thyroiditis but no enlargement of the thyroid gland. Conclusion: TSH and fT3 levels were found to be higher in obese children compared with non-obese children with no difference of fT4 levels between two groups.

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