Asuman BİÇER, Nurcan BAŞAR, Betül Banu KARASU, Özlem KARAKURT, Harun KILIÇ, Mehmet DOĞAN, Münevver SARİ, Havva Kaya AKIŞ, Fatma ESKİOĞLU, Ramazan AKDEMİR

Psöriazis hastalarında artmıs QT dispersiyonu

Amaç: Psöriazis, genellikle diz, dirsek, saçlı deri, umblikus ve lomber alanda ortaya çıkan gümüsi beyaz renkli kepeklenmelerle kaplı eritemli plaklarla karakterize, kronik infl amatuar bir deri hastalığıdır. Psöriaziste kardiyovasküler bozukluklar dahil çok sayıda sistemik hastalık tanımlanmıstır. Biz bu çalısmada psöriazis hastalarında, ventriküler aritmilerin artısı ve ani kardiyak ölüm riskinin muhtemel bir göstergesi olan QT dispersiyonunu (QTD) ve düzeltilmis QT dispersiyonunu (QTcD) değerlendirmeyi planladık. Gereç ve Yöntemler: Çalısmaya psöriazisli 23 hasta ve yas ve cinsiyet açısından hasta grubu ile benzerlik gösteren sağlıklı 20 kontrol bireyi alındı. Hastalığın ciddiyetinin değerlendirilmesinde, “Psoriazis Alan Siddet İndeksi” (PASİ) kullanıldı. Tüm bireylere 25 mm/sn hızında 12 derivasyonlu elektrokardiyografi çekildi ve 24 saatlik holter monitorizasyonu yapıldı. QTD ve QTcD ölçümleri yapıldı. QTD, en büyük ve en küçük QT değerleri arası fark olarak tanımlandı ve düzeltilmis QT (QTc) Bazett formülüne göre hesaplandı. QTD ve QTcD ile PASİ ve hastalık süresi arasında korelasyon analizi yapıldı. Bulgular: QTD ve QTcD hasta grubunda kontrol grubundan istatistiksel olarak anlamlı düzeyde yüksek tespit edildi (QTD; sırasıyla, 67.5±17.4 ve 44.0±11.9 ms, p

Increased QT dispersion in patients with psoriasis

Objectives: Psoriasis is a chronic infl ammatory skin disorder characterized by erythematous plaques, generally at the elbows, knees, scalp, umbilicus and lumber area. Many systemic diseases including cardiovascular disturbances have been described in psoriatic patients. In the present study, we aimed to investigate QT dispersion (QTD) and corrected QT dispersion (QTcD) as a possible indicator of increased risk for ventricular arrhythmias and sudden cardiac death in patients with psoriasis. Materials and methods: Twenty-three patients with psoriasis and age and gender matched 20 control subjects were enrolled in the study. The severity of the disease was evaluated by the “Psoriasis Area and Severity Index (PASI)”. Standard 12-lead electrocardiographs at 25 mm/s paper speed and 24-hour holter examination were performed in all subjects. QTD and QTcD were measured. QTD was defi ned as the difference between the maximum and minimum QT interval measurements and QTc was calculated according to Bazett’s formula. Correlation analysis was performed between QTD and QTcD and PASI and duration of the disease. Results: QTD and QTcD were signifi cantly greater in psoriatic patients than controls (QTD, 67.5±17.4 vs 44.0±11.9 ms, p<0.001, respectively; QTcD, 72.4±17.6 vs 47.8±12.8 ms, p<0.001, respectively). There were a positive correlation between QTD and QTcD and PASI and longevity of psoriasis disease. Conclusion: In the present study, the patients with psoriasis have an increased QTD and QTcD when compared with healthy subjects and this increase was found to be correlated with the duration and severity of the disease.

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