Cennet YILDIZ, Abdülmelik YILDIZ, Fatih TEKİNER

Premenopozal ve postmenopozal kadınlarda lipit profili ve plazma aterojenik indeksinin karşılaştırılması

Amaç: Menopoz ile birlikte hormonal durum, metabolizma ve lipit profilinde bir takım değişiklikler meydana gelir. Çalışmamızın amacı yaşın ve menopozun lipit profilinde meydana getirdiği değişiklikleri incelemektir. Yöntemler: Çalışmaya sağlıklı 160 postmenopozal ve 260 premenopozal kadın alındı. Tüm olgulara bir anket formu doldurtuldu. Tüm olguların total kolesterol (TK), yüksek yoğunluklu lipoprotein kolesterol (HDL-K), düşük yoğunluklu lipoprotein kolesterol (LDL-K), trigliserid (TG) ve plazma aterojenik indeksi (PAI) değerlendirildi. Premenopozal kadınlar ayrıca 22-45 yaş ile ve 45 yaş üzeri olmak üzere iki gruba ayrıldı. Bulgular: Menopoz sonrası kadınlarda TK, LDL-K, TG ve PAI değerleri anlamlı olarak yüksek bulunurken, HDL-K seviyesinde anlamlı fark saptanmadı. Kırk beş yaş üzeri premenopozal kadınlarda sadece LDL-K seviyesi anlamlı olarak yüksek bulundu. Sonuç: Menopoz lipit profilinde değişiklikler ile birliktedir. Plazma aterojenitesi için bir belirleyici olan PAI, postmenopozal kadınlarda ateroskleroz riski için kullanılabilir.

Comparison of serum lipid profle and plasma atherogenic index between premenopausal and postmenopausal women

Objective: Menopause leads to changes in hormonal status, metabolism and lipid profle. The aim of the present study was to determine the infuence of menopause and age on lipid profle in women. Methods: This study included 160 postmenopausal and 260 premenopausal healthy women. Serum lipid profle including total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and atherogenic index of plasma (AIP) were estimated. Premenopausal women were further arranged in to two different age group of 22-45 years and above 45 years of age. The premenopausal and postmenopausal women were recruited and classifed using a comprehensive questionnaire. Results: There were statistically signifcant increases in TC, LDL-C, TG and AIP but there was no signifcant difference in HDL-C level between premenopausal and postmenopausal women. Only LDL-C level was signifcantly increased in premenopausal women above 45 years of age compared with the premenopausal women between 22-45 years of age. Conclusion: Menopause alters lipid profle. Atherogenic index of plasma which is a marker of plasma atherogenicity may be used to asses risk of developing atherosclerosis in postmenopausal women.

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