MURAT YAVUZ, PELİN KÖSE YAMAN, Nurdan ÖZTÜRK, SUNA TİMUR, ELİF SUBAŞI

p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

Amaç: Farmakolojik olarak ilgi çekici özelliklere sahip rutenyum komplekslerinin gelişimine katkıda bulunmak amacıyla tiyosemikarbazon (TSC) içeren üç yeni mononükleer rutenyum(II)-aren kompleksleri sentezlendi. Yöntemler: Rutenyum(II)-aren dimeri [{RuCl(?-Cl)(?-p-simen)}2] (1) sırasıyla TSC1-3 (1:2 molar oranda) ile metanol içerisindeki reaksiyonu sonucu p-simen içeren konformasyonel olarak rijit yarı-sandviç Ru(II)-aren kompleksleri; [(?6-p-simen)Ru(TSC1-?3O,N,S)]Cl (I), [(?6-p-simen)Ru(Cl)(TSC2-?2N,S)]Cl (II), ve [(?-p-simen)Ru(Cl)(TSC3-?2N,S)]Cl (III) bileşikleri sentezlendi. Kompleks I, II ve III'ün moleküler yapıları elementel analiz teknikleri ve 1H NMR, Fourier transform infrared (FT-IR), UV-vis uygulamaları ile elde edilen spektroskopik veriler temelinde aydınlatıldı. Sentezlenen üç rutenyum(II)-aren kompleksinin in vitro antimikrobiyal aktivitesi disk difüzyon metodu ile değerlendirildi. Bulgular: Spektroskopik veriler TSC1'in kompleks I'de tiyon sülfür atomu, fenolik oksijen atomu ve azometin azot atomu üzerinden üç-dişli ligant olarak metale bağlanırken, TSC2 ve TSC3'ün kompleks II ve III'te tiyon sülfür atomu ve imin azot (C=N) atomu üzerinden çift-dişli ligant olarak merkezi metal atomuna bağlandığını ortaya koymuştur. Gözlemlenen antimikrobiyal aktivite sonuçları komplekslerin Gram-pozitif bakteri suşlarının büyümelerini etkin bir biçimde inhibe ettiğini göstermiştir. Sonuç: TSC1-3 içeren yeni mononükleer rutenyum(II)-aren kompleksleri başarılı bir biçimde sentezlendi ve moleküler yapıları spektroskopik yöntemlerle belirlendi. Bütün rutenyum(II)-aren kompleksleri Gram-negatif bakterilerden ziyade Gram-pozitif bakterilere karşı yüksek antimikrobiyal aktivite gösterdi.

Objective: Thiosemicarbazone (TSC) containing three new mononuclear ruthenium(II)-arene complexes were synthesized so as to contribute to the development of ruthenium complexes with pharmacologically attracted properties. Conclusion: The TSC1-3 containing ruthenium(II)-arene complexes were successfully synthesized and their molecular structures were also determined by the spectroscopic methods. All ruthenium(II)-arene complexes showed higher antibacterial activities against Gram-positive bacterial strains than the Gram-negative ones

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