Guillain-Barre sendromunda klinik ve demografik özellikler

Amaç: Guillain-Barre Sendromlu (GBS) hastaların epidemiyolojik, klinik, laboratuvar ve elektrofizyolojik bulguları değerlendirilmesi amaçladık. Yöntemler: Çalışmaya Güneydoğu Anadolu bölge nüfusunu temsil ettiği düşünülen Dicle üniversitesi tıp fakültesi hastanesi nöroloji kliniğine Ocak 2011 ve Mart 2014 yılları arasında başvurmuş ve yatırılarak takip edilen 36 olgunun dosya kayıtları geriye dönük olarak incelendi. Tüm hastaların demografik, klinik, laboratuar, BOS, elektrofizyolojik ve tedavi verileri kaydedildi. Bulgular: Guillain-Barre Sendromu tanısı alan 36 olgunun 22 (%61,1)u erkek ve 14 (%38,9)i kadındı. Klinik ve elektrofizyolojik verilerine göre 22 hasta (%61,1) Akut İnflamatuar Demiyelinizan Polinöropati (AIDP), 4 hasta (%11,1) Akut Motor Aksonal Nöropati (AMAN), 8 hasta (%22,2) Akut Motor ve Sensoryal Aksonal nöropati (AMSAN) ve 2 hasta (%5,6) Miller Fisher Sendromu (MFS) olarak değerlendirildi. Hastaların çoğunda öncül bir hastalık mevcuttu. 13 hastada (%36,1) üst solunum yolu enfeksiyonu (ÜSYE) , 10 hastada (%27,8) gastroenterit, 4 hastada(%11,1) cerrahi, bir hastada(%2,8) aşı öyküsü mevcuttu. Sonuç: Çalışmamız GBSyi cerrahi işlemlerin tetikleyebileceğini ve GBSnin etyopatogenezinde coğrafyanın ve çevresel faktörlerin önemini göstermektedir.

Clinical and demographic characteristics of Guillain-Barre syndrome

Objective: We aimed to assess the epidemiological, clinical, laboratory, electrophysiological findings in patients with Guillain-Barre´ syndrome Methods: We performed a retrospective analysis of 33 patients with GBS admitted to Dicle University Medical Faculty Hospital neurology clinic from January 2011 to March 2014. Were reviewed. Epidemiological, clinical, therapeutical and evolutionary data were collected. Results: Thirty-six patients with the diagnosis of GBS included 22 males and 14 females. The average age at diagnosis was 41.3±21.38years with a wide age range (11–82) and a peak between 36 and 55 years. Based on clinical and electrophysiological features, 61.1% of the patients had acute inflammatory demyelinating polyneuropathy (AIDP), 22.2% acute motor and sensory axonal neuropathy 11.1% had acute motor axonal neuropathy, and 5.6% had Miller Fisher Syndrome. In 28 of 36 patients (77.0%), potential trigger factors could be identified. Respiratory tract infection was the most common infection (36.1%), followed by gastrointestinal infection (27.8%), after surgery (11.1%), vaccination (2.8%) Conclusion: Our study showed that surgery may be triggered GBS and suggesting a geographical and environmental factor involved in GBS etiopathogenesis.

___

  • 1. Van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome. Lancet Neurol 2008;7:939–950.
  • 2. Pithadia AB, Kakadia N. Guillain–Barre syndrome (GBS). Pharmacol Rep 2010;62:220-232.
  • 3. Algahtani H, Moulin DE, Bolton CF, Abulaban AA. Guillain–Barre syndrome following cardiac surgery. Difficult diagnosis in the intensive care unit. Neurosciences (Riyadh) 2009;14:374–378.
  • 4. Campbell AJ, McKinlay K, Scott NB. Guillain–Barre syndrome after cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2009;23:82–83.
  • 5. McGrogan A, Madle G, Seaman HE, De Vries CS. The epidemiology of Guillain-Barré syndrome worldwide. Neuroepidemiology 2009;32:150–155.
  • 6. Korinthenberg R, Schessl J, Kirschner J. Clinical presentation and course of childhood Guillain-Barré syndrome: a prospective multicentre study. Neuropediatrics 2007;38:10–17.
  • 7. Soysal A, Aysal F, Calıskan B.Clinico-electrophysiological findings and prognosis of Guillain-Barre´ syndrome 10 years experienceActa. Neurol Scand 2011;123:181–186
  • 8. The Italian Guillain-Barré Study Group: The prognosis and main prognostic indicators of GuillainBarré syndrome. A multicentre prospective study of 297 patients. Brain 1996;119:2053–2061.
  • 9. Van Koningsveld R, Steyerberg EW, Hughes RAC, et al. A clinical prognostic scoring system of Guillain-Barré syndrome. Lancet Neurol 2007;6:589–594.
  • 10. Hughes RA, Newsom-Davis JM, Perkin GD, Pierce JM. Controlled trial prednisolone in acute polineuropathy. Lancet 1978;2:750–753.
  • 11. Medical Research Council. Aids to the examination of the peripheral nervous system, Memorandum no. 45, Her Majesty’s Stationery Office, London, 1981.
  • 12. Jiang GX, Cheng Q, Ehrnst A, Link H, De Pedro-Cuesta J. Guillain-Barre´ syndrome in Stockholm County, 1973– 1991. Eur J Epidemiol 1997;13:25–32.
  • 13. Lyu R-K, Tang L-M, Cheng S-Y, et al. Guillain-Barre´ syndrome in Taiwan: a clinical study of 167 patients. J Neurol Neurosurg Psychiatry 1997;63:494–450.
  • 14. Gazioğlu S, Tomak T, Boz C. Guillain-BarreSendromunda Klinik Özellikler ve Prognoz. J Neurol Sci [Turk] 2013;34:124-134.
  • 15. Markoula S, Giannopoulos S, Sarmas I, et al. GuillainBarre syndrome in northwest Greece. Acta Neurol Scand 2007;115:167-173.
  • 16. González-Suárez et al. Guillain-Barré Syndrome: Natural history and prognostic factors: a retrospective review of 106 cases. BMC Neurology 2013;13:95.
  • 17. Cuadrado JI, de Pedro Cuesta J, Ara JR, et al. GuillainBarré syndrome in Spain, 1985–1997: epidemiological and public health view. Eur Neurol 2001;46:83–91.
  • 18. Alandro-Benito Y, Conde-Sendín MA, Muñoz-Fernández C, et al. Síndrome de Guillain-Barré en el área norte de Gran Canaria e isla de Lanzarote. Rev Neurol (Barc.) 2002;35:705–710.
  • 19. Gensicke H, Datta AN, Dill P, et al. Increased incidence ofGuillain–Barre syndrome after surgery. Eur J Neurol 2012;19:1239–1244.
  • 20. Hogan JC, Briggs TP, Oldershaw PJ. Guillain–Barre syndrome following cardiopulmonary bypass. Int J Cardiol 1992;35:427–428.
  • 21. Renlund DG, Hanley DF, Traill TA. Guillain–Barre syndrome following coronary artery bypass surgery. Am Heart J 1987;113:844
  • 22. Oucquey D, et al. Clinical and serological studies in a series of 45 patients with Guillain–Barre syndrome. J Neurol Sci 1991;104:56–63.
  • 23. Vucic S, Kiernan MC, Cornblath DR. Guillain-Barre´ syndrome: an update. J Clin Neurosci 2009;16:733–741.
  • 24. Mori M, Kuwabara S, Fukutake T, et al. Clinical features and prognosis of Miller Fisher syndrome. Neurology 2001;56:1104-1106.
  • 25. Kushnir M, Klein C, Pollak L, Rabey JM. Evolving pattern of Guillain-Barre syndrome in a community hospital in Israel. Acta Neurol Scand 2008;117:347-350.
Dicle Tıp Dergisi-Cover
  • ISSN: 1300-2945
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1963
  • Yayıncı: Cahfer GÜLOĞLU
Sayıdaki Diğer Makaleler

Hemşirelerin çalıştıkları bölümlere göre ötanazi hakkındaki görüşlerinin değerlendirilmesi

Bekir KARAARSLAN, CEM UYSAL, Yusuf ATAN, Zekeriya TATAROĞLU, İsmail BOZKURT, TAHSİN ÇELEPKOLU, Halis TANRIVERDİ, Süleyman GÖREN

Siringomanın nadir olarak izlenen berrak hücreli varyantı

Özben YALÇIN, Fatih Mert DOĞUKAN, Fevziye KABUKÇUOĞLU, ASLI AKSU ÇERMAN, İlknur Kıvanç ALTUNAY

Metabolik olarak sağlıklı ve sağlıksız obez hastalarda ürik asit seviyeleri

EMİN MURAT AKBAŞ, ADALET ÖZÇİÇEK, FATİH ÖZÇİÇEK, LEVENT DEMİRTAŞ, AYSU TİMUROĞLU, Adem GÜNGÖR, Nergis AKBAŞ

Sigara kullanıcılarda nikotin bağımlılık düzeyinin yaş ve cinsiyetle ilişkisi: Diyarbakır örneklemi

TAHSİN ÇELEPKOLU, Abdullah ATLI, Yılmaz PALANCI, Ahmet YILMAZ, Süleyman DEMİR, ASLIHAN OKAN İBİLOĞLU, SELAMİ EKİN

Benign eklem hipermobilite sendromlu hastalarda emosyonel durum ve ilişkili faktörler

Serda EM, MEHMET ÇAĞLAYAN, PELİN OKTAYOĞLU, Mehtap BOZKURT, Veysi CEYLAN, Kemal NAS

Karotis artere stent yerleştirme: Tek merkez deneyimi ve klinik sonuçları

NİHAT POLAT, Mehmet Ali ELBEY, EŞREF AKIL, Habib ÇİL, Necdet ÖZAYDOĞDU, MEHMET ATA AKIL, Murat ÇAYLI

Kolorektal kanserlerde prognostik faktörler

Ahmet TÜRKOĞLU, Ziya ÇETİNKAYA, Mustafa GİRGİN, REFİK AYTEN, BURHAN HAKAN KANAT, Kenan BİNNETOĞLU, Ali AKSU

Postmortem biyokimya

MUKADDES GÜRLER, Aynur ALTUNTAŞ

Laparoskopik radikal nefrektomi deneyimlerimiz

MANSUR DAĞGÜLLİ, Mehmet Mazhar UTANĞAÇ, Yaşar BOZKURT, ONUR DEDE, Mehmet Nuri BODAKÇI, Ahmet Ali SANCAKTUTAR, Necmettin PENBEGÜL, Namık Kemal HATİPOĞLU

Posttraumatic basal ganglia infarction: A rare complication in a child after mild head injury

Ahmet METE, Duçem METE, SEDAT IŞIKAY