Gestational diabetes mellitus diagnosed in different periods of gestation and neonatal outcome

Amaç: Gebeliğin farklı dönemlerinde gestasyonel diabet tanısı alan kadınlarda anne ve bebek sonuçlarını değerlendirmek Gereç ve Yöntem: Bu tanımlayıcı gözlemsel çalışma Pakistan’daki 1300 yataklı “Bahawal Victoria Hastanesi” Kadın-Doğum Kliniğinde 1 Ocak-31 Aralık 2007 tarihleri arasında gerçekleştirildi. Oral glukoz tolerans testi sonucuna göre Ulusal Diabet Veri Grubu kriterlerine uyan 76 gebe kadın diabet tanısı aldı. Çalışma grubundaki hastalar gestasyonel diabetin (GDM) ilk tanı anındaki gebelik dönemine göre Grup A (gebelik haftası 13-23 arası), Grup B (24-30 haftalık gebelik) ve Grup C (31-36 haftalık gebelik) olarak alt gruplara ayrıldı. Bulgular: Toplam çalışma grubundan 19 (%25)’u erken başlangıçlı GDM (13-23 hafta), 25 (%32.9)’u 24-30 haftada, 32 (%42.1)’i 31-36 haftada (geç başlangıçlı GDM idi. Erken başlangıçlı GDM’li grupta gebelik ilintili hipertansiyon 5 (%26.3), polihidramniyos 5 (%26.3), insülin tedavisi 13 (%68.4)’ünde görüldü ve bu oranlar diğer dönemlerdeki hastalardan daha yüksekti (p

Gebelik diyabeti ve yenidoğana etkisi

Objective: To evaluate the maternal and neonatal outcomes in women diagnosed as gestational diabetes mellitus (GDM) in different periods of pregnancy. Materials and Methods: This descriptive observational study was carried out from 1st January 2007 to 31th December 2007 in the department of Obstetrics and Gynecology of a 1300 bedded tertiary care hospital "Bahawal Victoria Hospital" in Bahawalpur, Pakistan. Seventy six pregnant women met the inclusion criteria of diabetes diagnosed on the basis of the Oral glucose tolerance test (OGTT) according to the National Diabetic Data Group. The study subjects were divided on the basis of gestational age at the first time diagnosis of GDM in the current pregnancy into group A (gestational age 13-23 weeks), group B (24-30 weeks) and group C (31-36 weeks). Results: Out of total study subjects, 19 (25%) were diagnosed as GDM between 13-23 weeks of gestation (early-onset), 25 (32.9%) between 24-30 weeks while 32 (42.1%) diagnosed in the gestational age of 31-35 weeks (late-onset). Pregnancy-induced hypertension 5 (26.3%), polyhydramnios 5 (26.3%) and insulin treatment 13 (68.4%) were higher in women with earlier GDM diagnosis (p<0.05). APGAR score at 5-min below seven was seen in 3 (15.8%), large for gestational age in 5 (26.3%), respiratory distress in 6 (31.5%) and pre-term delivery in 5 (26.3%) of the early GDM group. These complications were seen more frequently in the early group compared with late-onset GDM group (p<0.05). Conclusion: Earlier diagnosis of GDM was seem to be associated with less favorable newborn outcome.

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  • 1. American diabetes association. Preconception care of women with diabetes mellitus. Diabetes Care 2003;26:S91-93.
  • 2. Persson B, Hanson U. Neonatal morbidities in gestational diabetes mellitus. Diabetes Care 1998;21(suppl.2):B79–B84.
  • 3. Kjos S, Buchanan T. Gestational diabetes mellitus. N Engl J Med 1999;341:1749-1756.
  • 4. Langer O. Is normoglycemia the correct threshold to prevent complications in the pregnant diabetic patient? Diabetes Reviews 1996;4:2-10.
  • 5. Farrell T, Neale L, Cundy T. Congenital anomalies in the offspring of women with type 1, type 2 and gestational diabetes. Diabet Med 2002;19:322-326.
  • 6. Schaefer U, Songster G, Xiang A, Berkowitz K, Buchanan TA, Kjos SL. Congenital malformations in offspring of women with hyperglycemia first detected during pregnancy. Am J Obstet Gynecol 1997;177:1165-1171.
  • 7. Metzger BE, Coustan DR. Summary and Recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care 1998;21(suppl.2):B161-167.
  • 8. Bartha J, Martinez P, Comino R. Gestational diabetes mellitus diagnosed during early pregnancy. Am J Obstet Gynecol 2000;182:346-350.
  • 9. Meyer WJ, Carbone J, Gauthier DW, Gottmann DA. Early gestational glucose screening and gestational diabetes. J Reprod Med 1996;41:675-679.
  • 10. Bartha JL, Martinez-Del-Fresno P, Comino-Delgado R. Early diagnosis of gestational diabetes mellitus and prevention of diabetes related complications. Eur J Obstet Gynecol Reprod Biol 2003;9:41-44.
  • 11. National Diabetes Data Group. Classification: and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979;28):1039-1057.
  • 12. Gillmer MDG, Hurley PA. Diabetes and endocrine disorders in pregnancy. In: Edmonds DK, editor. Dewhurst’s Textbook of obstetrics and gynaecology for postgraduates. 6th ed. Oxford: Blackwell Science 1999. p. 197-209.
  • 13. Goldstein SR. Embryonic ultrasonographic measurements: crown-rump length revisited. Am J Obstet Gynecol 1991;165:497-501.
  • 14. Nasrat AA, Augensen K, Abushal M, Shalhoub JT. The outcome of pregnancy following untreated impaired glucose tolerance. Int J Gynaecol Obstet 1994;47:1-6.
  • 15. Tan YY, Yeo GS. Impaired glucose tolerance in pregnancy – is it of consequence? Aust N Z J Obstet Gynaecol 1996 ;36:248-255.
  • 16. Deerochanawong C, Putiyanum C, Wongsuryrat M, Serirat S, Jinayon P. Comparison of National Diabetes Data Group and World Health Organization criteria for detecting gestational diabetes mellitus. Diabetologia 1996;39:1070-1073.
  • 17. Jacobson JD, Cousins L. A population-based study of maternal and perinatal outcome in patients with gestational diabetes. Am J Obstet Gynecol 1989;161:981-986.
  • 18. Beischer NA, Oates JN, Henry OA, Sheedy MT, Walstab JE. Incidence and severity of gestational diabetes mellitus according to country of birth in women living in Australia. Diabetes 1991;40 (Suppl 2): 35-38.
  • 19. Sermer M, Naylor CD, Farine D, et al. The Toronto Tri- Hospital Gestational Diabetes Project . A preliminary review. Diabetes Care 1998;21(Supplement 2):B33-42.
  • 20. El-Shafei A, Bashmi Y, Norman A. Incidence and severity of gestational diabetes in Bahrain and Australia. Aus NZ J Obstet Gyneacol 1989;29:204-209.
  • 21. Moses RG, Colagiuri S. The extent of undiagnosed gestational diabetes mellitus in New South Wales. Med J Aust 1997;167:14-16.
  • 22. Berkowitz G, Roman S, Lapinski R. Maternal characteristics, neonatal outcome, and the time of diagnosis of gestational diabetes. Am J Obstet Gynecol 1992;167(4 pt 1):976-982.
  • 23. Svare J, Hansen B, Molsted-Pedersen L. Perinatal complications in women with gestational diabetes mellitus. Acta Obstet Gynecol Scand 2001;80:899-904.
  • 24.Super D, Edelberg S, Philipson E, Hertz R, Kalhan S. Diagnosis of gestational diabetes in early pregnancy. Diabetes Care 1991;14:288-294.
  • 25. Moses RG, Griffiths RD. Can a diagnosis of gestational diabetes be an advantage to the outcome of pregnancy? J Soc Gynecol Investig. 1995;2:523-525.
  • 26. Leipold H, Worda C, Gruber CJ, Kautzky-Willer A, Husslein PW, Bancher-Todesca D. Large-for-gestational-age newborns in women with insulin-treated gestational diabetes under strict metabolic control. Review Group(s): Cochrane Child Health Field, Cochrane Metabolic and Endocrine Disorders Group. Source: Wiener Klinische Wochenschrift 2005;117:521-525.
  • 27. Malinowska-Polubiec A, Czajkowski K, Sotowska A. Pregnancy and delivery course in patients with gestational diabetes mellitus. Ginekol Pol 2003;74:1200-1207.
Dicle Tıp Dergisi-Cover
  • ISSN: 1300-2945
  • Yayın Aralığı: 4
  • Başlangıç: 1963
  • Yayıncı: Cahfer GÜLOĞLU