Ali Veysel KARA, Sema TANRİKULU, EMRE AYDIN, FATMA YILMAZ AYDIN, Hikmet SOYLU, YAŞAR YILDIRIM, ZÜLFÜKAR YILMAZ, ALİ KEMAL KADİROĞLU, MEHMET EMİN YILMAZ

Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis

Amaç: Akut böbrek hasarı (AKI) sepsisli hastalarda mortaliteyi arttırdığı bilinen önemli bir klinik tablodur.Eritrosit maturasyonu ve profilerasyonu, proinflamatuar sitokinler tarafından inhibe edilir. Bu sitokinler eritrosit dağılım genişliği üzerinde etkilidirler. Bu ilgiye dayanarak sepsisli hastalarda eritrosit dağılım genişliğinin (rRDW) akut böbrek hasarı gelişimi üzerine etkisini değerlendirmeyi amaçladık. Yöntemler: 2009-2013 yılları arasında sepsis tanısı olan ve yoğun bakım ünitesine kabul edilen 120 hastayı retrospektif olarak inceledik. hastaları grup 1 (RDW>=16.8) ve grup 2 (RDW

Eritrosit dağılım genişliğinin sepsisli hastalarda akut böbrek hasarı gelişimi üzerine etkisinin değerlendirilmesi

Objective: Acute kidney injury (AKI) is an important clinical entity that is known to increase mortality in patients with sepsis. Erythrocyte maturation and proliferation are inhibited by pro-inflammatory cytokines; these cytokines exert effects on red cell distribution width (RDW) well. Based on this knowledge; our aim in this study was to evaluate the impact of RDW on acute kidney injury in patients with sepsis. Methods: 120 patients diagnosed with sepsis and admitted to intesive care unit (ICU) and treated between 2009-2013 were retrospectively evaluated. Patients were divided into two groups as follows: group 1 (RDW>=16.8) and group 2 (RDW<16.8). Multiple logistic regression analysis was used to determine the association between RDW and AKI and mortality. Results: There was a statistically significant relationship between AKI and RDW (p<0.001, OR=11.52) but there were no statistically significant relationship between AKI and sex, age, serum lactate levels as well as SOFA score. Also, there were statistically significant relationship between mortality and RDW (p=0.044, OR=5), serum lactate levels (p=0.030) and SOFA score (p<0.001). RDW was found associated with both AKI and mortality. Conclusions: Results suggest that RDW is an important parameter for predicting development of AKI and mortality in ICU patients with sepsis

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