Effects of Thymoquinone on Oxidative Stress in the Testicular Tissue of Reserpinized Rats

Objective: The objective of the study was to research the oxidant and antioxidant activity of Thymoquinone (TQ) in the testicular tissue of Reserpinized rats. Methods: Eighteen rats were divided into three groups and each group had six animals: 1) Control (C) group: Received ip. 1% Tween 80; 2) Reserpine (R) group: Received Reserpine; 3) Reserpine + TQ (R+T) group: Received Reserpine and TQ. Reserpine was injected intraperitoneally 0.2 mg/kg and TQ was administered intragastrically 10 mg/kg once daily. The rats were treated for 14 consecutive days. At the end of the study, total nitric oxide (NOx) levels, malondialdehyde (MDA) levels and glutathione (GSH) levels in the testicular tissue were examined. Results: A statistically significant increase was observed in the NOx levels (p=0.001) and MDA levels of testicular tissue in the R group (p

Reserpinize Sıçanların Testis Dokusunda Oksidatif Stres Üzerine Thymoquinone'nin Etkisi

Amaç: Çalışma Reserpinize sıçanların testis dokusunda Thymoquinone (TQ)’ nun oksidan ve antioksidan etkinliğini araştırmak amacıyla yapıldı. Yöntemler: 18 adet Wistar Albino sıçan her grupta 6 sıçan olacak şekilde 3 eşit gruba ayrıldı. Kontrol(K) grubu: intraperitoneal %1 Tween 80 verildi. Reserpin(R): Reserpine verildi. Reserpine+TQ (R+T): Reserpine ve TQ verildi. Reserpin intraperitoneal 0.2 mg/kg enjekte edildi ve TQ intragastrik 10 mg/kg günde bir kere verildi. Deney ardışık 14 gün sürdü. Çalışmanın sonunda testis dokusunda toplam nitrik oksit (NOx), malondilaldehit (MDA) ve glutatyon (GSH) düzeyleri bakıldı. Bulgular: R grubunda testis dokusunun NOx düzeylerinde (p=0.001) ve MDA düzeylerinde istatistiksel olarak önemli bir artış oldu (p

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