Ahmet ÇALIŞKAN, SÜLEYMAN YAZICI, OĞUZ KARAHAN, Sinan DEMİRTAŞ, Celal YAVUZ, ORKUT GÜÇLÜ, Orhan TEZCAN, Binali MAVİTAŞ

Derin ven trombozunda tam kan sayımı parametrelerinin araştırılması

Amaç: Derin ven trombozunun (DVT) seyrinde inflamasyonun rolü çeşitli çalışmalarda açıklanmıştır. Bu nedenle literatürde inflamatuar belirteçlerin bu hastalıkta rolü araş- tırılmıştır. Son dönemde, tam kan sayımı parametreleri (Hemogram) arasında inflamatuar belirteçlerin kısa ifadesi olarak nötrofil lenfosit oranı (NLR), platelet lenfosit oranı (PLR) gibi belirteçler sıkça kullanılmaya başlanmıştır. Bu çalışma da hemogram parametrelerinin DVT ile ilişkisi incelenmiştir. Yöntemler: Kliniğimize akut DVT tanısı ile başvuran 50 hasta (28 kadın, 22 erkek) çalışmaya dahil edildi. Hastaların tanıları klinik semptomlar ve Doppler ultrasonografi ile konuldu. Hastalardan ek inflamatuar cevap oluşturacak hastalığı olanlar değerlendirme dışı bırakıldı. Kontrol grubu olarak da 30 sağlıklı gönüllü seçildi. Bu hastaların retrospektif olarak rutin hemogram sonuçları değerlendirildi. Rutin hemogram parametreleri ve nonselektif inflamatuar belirteçler olan kırmızı hücre dağılım hacmi (RDW), beyaz küre (WBC), NLR, PLR nin ölçümleri istatistiksel olarak incelendi. Bulgular: Çalışmaya alınan hastaların yaş ortalaması 46.2±14.2 yıl olup %53ü kadın cinsiyette idi. Gruplar hematolojik parametreler açısından incelendiğinde DVT grubunda lenfosit (2.6±0.8 ve 2.1±0.7, p=0.003) ve platelet miktarları (322±144 ve 264±66, p=0.042) daha yüksek, hemoglobin (13.2±2.0 ve 14.6±1.5, p=0.002) ve hematokrit değerleri (38.7±5.1 ve 42.8±6.9, p

The investigation of complete blood counting parameters in deep venous thrombosis

Objective: The role of inflammation in the deep venous thrombosis (DVT) process has been explained in various studies. Hence, the role of inflammatory markers in this illness has been researched previouslyin the literature. Recent years, such as parameters, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR), among complete blood count have been frequently started to use as an expression of inflammatory marker. In the current study, the relation between complete blood count parameters and DVT was investigated. Methods: 50 patients admitted to our clinic with the diagnosis of acute DVT (28 female, 22 male) were included in the study. The patients were diagnosed by clinical symptoms and Doppler USG. Patients with additional illness that can form an inflammatory response were excluded. 30 healthy volunteers were included as a control group. Routine complete blood counts of these patients were examined retrospectively. Routine complete blood counts and nonselective inflammatory markers, red cell distribution width (RDW), white cells (WBC), NLR, and PLR measurements were examined statistically. Results: The mean age of patients included in study was 46.2±14.2 and 53% of them were female. When the groups were examined in terms of hematological parameters, lymphocyte (2.6±0.8 and 2.1±0.7, p=0.003) and platelet (322±144 and 264±66, p=0.042) values were detected to be higher. Hemoglobin (13.2±2.0 and 14.6±1.5, p=0.002) and hematocrit (38.7±5.1 and 42.8±6.9, p<0.001) values were detected to be less while the WBC, neutrophil, NLR, RDW and PLR were similar. Regarding the two groups with and without anticoagulant therapy, in the DVT group, there were no significant differences detected in terms of age, gender, and hematological parameters. Conclusion: In this study, there were no significant differences between healthy volunteers blood count parameters of patients taken into consideration with pure DVT. There is no significant change shown.

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