Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control

Objective: Inadequate control of glycemia in diabetic patients is the primary cause of both micro- and macrovascular complications. Several components of complete blood count were investigated and have found to be higher in diabetic patients. We aimed to evaluate white blood cell (WBC), neutrophil, lymphocyte and platelet counts and, red cell distribution width (RDW), mean platelet volume (MPV) and platelet distribution width (PDW) in type 2 diabetes mellitus (T2DM) patients with inappropriorate glycemic management (HbAlc >7%) despite using insulin therapy. Methods: 135 type 2 diabetic patients with inappropriorate blood glucose management (HbAlc value >7 %) despite using insulin therapy for at least 3-month period (only insulin or insulin plus oral hypoglycemic agents) and 121 healthy subjects were included in the study. Demographic, anthropometric and laboratory data were recorded. Results: WBC, neutrophil, lymphocyte and monocyte counts were higher in DM group (p

Yetersiz Glisemik Kontrolü Olan Tip 2 Diyabet Hastalarında Tam Kan Sayımı Parametreleri

Amaç: Diyabetik hastalarda yetersiz glisemik kontrol mikro- ve makrovasküler komplikasyonların gelişmesinde önemli bir risk faktörüdür. Çeşitli tam kan sayımı parametreleri diyabet hastalarında araştırılmış ve yüksek bulunmuştur. Bu çalışmada amacımız; lökosit, nötrofil, lenfosit sayıları ve red cell distribution width (RDW), mean platelet volume (MPV) and platelet distribution width (PDW) değerlerini insulin tedavisine rağmen yeterli glisemik kontrolün sağlanamadığı (HbAlc değeri >7%) tip 2 diyabetli hastalarda incelemektir Yöntemler: Çalışmaya en az 3 aydır insülin tedavisi almasına (sadece insülin ya da insülin+oral antidiyabetik ajan) rağmen yeterli glisemik kontrolün sağlanamadığı 135 tip 2 diyabet hastası ve 121 kontrol hastası alındı. Demografik, antropometrik ve laboratuvar verileri kaydedildi. Sonuçlar: Lökosit, nötrofil, lenfosit ve monosit sayıları diyabetli hastalarda daha yüksekti (p

___

Murphy AJ, Woollard KJ, Hoang A, et al. High-density lipoprotein reduces the human monocyte inflammatory response. Arterioscler Thromb Vasc Biol 2008; 28:2071–7.

Barter PJ, Baker PW, Rye K-A. Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells. Curr Opin Lipidol 2002; 13:285–8.

Gratchev A, Sobenin I, Orekhov A, et al. Monocytes as a diagnostic marker of cardiovascular diseases. Immunobiology 2012; 217:476–82.

Olivares R, Ducimetière P, Claude JR. Monocyte count: a risk factor for coronary heart disease? Am J Epidemiol 1993; 137:49–53.

Hansson GK. Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis. Circ Res 2002; 91:281–91.

Patel K V., Ferrucci L, Ershler WB, et al. Red Blood Cell Distribution Width and the Risk of Death in Middle-aged and Older Adults. Arch Intern Med 2009; 169:515.

Zalawadiya SK, Zmily H, Farah J, et al. Red cell distribution width and mortality in predominantly African-American population with decompensated heart failure. J Card Fail 2011; 17:292–8.

Perlstein TS, Weuve J, Pfeffer MA, et al. Red Blood Cell Distribution Width and Mortality Risk in a Community-Based Prospective Cohort. Arch Intern Med 2009; 169:588.

Buch A, Kaur S, Nair R, et al. Platelet volume indices as predictive biomarkers for diabetic complications in Type 2 diabetic patients. J Lab Physicians 2017; 9:84.

Papanas N, Symeonidis G, Maltezos E, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15:475–8.

Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J 2008; 49:114–6.

Ferroni P, Basili S, Falco a, et al. Platelet activation in type 2 diabetes mellitus. J Thromb Haemost 2004; 2:1282–91.

Van der Loo B, Martin JF. Megakaryocytes and platelets in vascular disease. Baillieres Clin Haematol 1997; 10:109–23.

Yilmaz H, Ucan B, Sayki M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr Clin Res Rev 2015; 9:299–304

Verdoia M, Schaffer A, Barbieri L, Aimaretti G, Marino P, Sinigaglia F, Suryapranata H DLGNASG (NAS). Impact of diabetes on neutrophil-to-lymphocyte ratio and its relationship to coronary artery disease. Diabetes Metab 2015; 41:304–11.

Shah AD, Denaxas S, Nicholas O, et al. Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study. J Am Coll Cardiol 2017; 69:1160–9.

Rana JS, Boekholdt SM, Ridker PM, et al. Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: The EPIC-Norfolk Prospective Population Study. J Intern Med 2007; 262:678–89.

Merten M, Thiagarajan P. P-selectin expression on platelets determines size and stability of platelet aggregates. Circulation 2000; 102:1931–6.

Mulvihill NT, Foley JB. Inflammation in acute coronary syndromes. Heart 2002; 87:201–4.

Vozarova B, Weyer C, Lindsay RS, et al. High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 2002; 51:455–61.

Schmidt MI, Duncan BB, Sharrett a R, et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999; 353:1649–52.

Duncan BB, Schmidt MI, Pankow JS, et al. Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study. Diabetes 2003; 52:1799–805.

Pickup JC, Mattock MB, Chusney GD, et al. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 1997; 40:1286–92.

Cetin MS, Ozcan Cetin EH, Kalender E, et al. Monocyte to HDL Cholesterol Ratio Predicts Coronary Artery Disease Severity and Future Major Cardiovascular Adverse Events in Acute Coronary Syndrome. Hear Lung Circ 2016; 25:1077–86.

Zhang Y, Li S, Guo Y-L, et al. Is monocyte to HDL ratio superior to monocyte count in predicting the cardiovascular outcomes: evidence from a large cohort of Chinese patients undergoing coronary angiography. Ann Med 2016; 48:305–12.

Chen X, Fang L, Lin H, Shen P, Zhang T, Li H, Li X, Yu M, Xu C, Zhang J, Lu F, DU X, Hu R ZJ. The Relationship between Type 2 Diabetes and Platelet Indicators. Iran J Public Heal 2017; 46:1211–6.

Nada AM. Red cell distribution width in type 2 diabetic patients. Diabetes, Metab Syndr Obes Targets Ther 2015; 8:525–33.

Wheeler JG, Mussolino ME, Gillum RF, et al. Associations between differential leucocyte count and incident coronary heart disease: 1764 Incident cases from seven prospective studies of 30 374 individuals. Eur Heart J 2004; 25:1287–92.

Tong PC, Lee KF, So WY, et al. White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care 2004; 27:216–22.

Hekimsoy Z, Payzin B, Ornek T, et al. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004; 18:173–6.

Gkrania-Klotsas E, Ye Z, Cooper AJ, et al. Differential white blood cell count and type 2 diabetes: Systematic review and meta-analysis of cross-sectional and prospective studies. PLoS One 2010; 5:e13405

Barbieri J, Fontela PC, Winkelmann ER, et al. Anemia in Patients with Type 2 Diabetes Mellitus. Anemia 2015; 2015:354737.

Madjid M, Awan I, Willerson JT, et al. Leukocyte count and coronary heart disease: Implications for risk assessment. J Am Coll Cardiol 2004; 44:1945–56.

Libby P. Inflammation in atherosclerosis. Nature 2002; 420:868–74.

Matheus a S, Tannus LR, Cobas R a, et al. Impact of diabetes on cardiovascular disease: an update. Int J Hypertens 2013;2013:653789.

Koro CE, Bowlin SJ, Bourgeois N, et al. Glycemic Control From 1988 to 2000 Among U.S. Adults Diagnosed With Type 2 Diabetes. Diabetes Care 2004; 27:17–20.

Guariguata L. By the numbers: New estimates from the IDF Diabetes Atlas Update for 2012. Diabetes Res Clin Pract 2012; 98:524–5.
Dicle Tıp Dergisi-Cover
  • ISSN: 1300-2945
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1963
  • Yayıncı: Cahfer GÜLOĞLU
Sayıdaki Diğer Makaleler

Association of signal transducer and activator of transcription, interleukin-6, and interleukin-10 positivity with antiviral treatment in cirrhotic liver samples from patients with the hepatitis B or C virus

Faik TATLI, Saime Hale KIRIMOĞLU, SEZAİ YILMAZ, Orhan GÖZENELİ, Cüneyt KAYAALP, Melih KARINCAOĞLU, Abuzer DİRİCAN, BORA BARUT, Vedat KIRIMLIOĞLU

Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control

Muhammed KIZILGÜL, Erkam Sencar, Bekir UÇAN, SELVİHAN BEYSEL, Özgür ÖZÇELİK, MUSTAFA ÖZBEK, ERMAN ÇAKAL

Long-term Outcomes of Surgical Management of Insulinoma: Single Center Experience

Abdullah ÜLKÜ, ORÇUN YALAV, AHMET GÖKHAN SARITAŞ, Ahmet RENCÜZOĞULLARI, Kubilay DALCI, İsmail Cem ERAY, Özgür YAĞMUR, Atılgan Tolga AKCAM

Eksozomlar ve Kanserdeki Rolleri

Süreyya BOZKURT

The Evaluation of Quality of Life of Relatives Caring for Patients with Parkinson’s Disease

FARUK ÖMER ODABAŞ, ALİ ULVİ UCA

Açık Tibia Kırıklarının Minimal İnvaziv Teknikle Kilitli Plakla Tedavinin Orta Dönem Sonuçları

RAMAZAN ATİÇ, CELİL ALEMDAR, ABUZER ULUDAĞ, SERDAR SARGIN, ABDULKADİR AYDIN, Ahmet KAPUKAYA

Güneydoğu Anadolu Bölgesindeki Üçüncü Basamak Gastroenteroloji Kliniğinin Toksik Hepatit Deneyimi

FEYZULLAH UÇMAK, Elif Tuğba TUNCEL, Hüseyin KAÇMAZ, Berat EBİK, Muhsin KAYA

Yetersiz Glisemik Kontrolü Olan Tip 2 Diyabet Hastalarında Tam Kan Sayımı Parametreleri

Erman CAKAL, Mustafa OZBEK, Selvihan BEYSEL, Muhammed KIZILGÜL, Ozgur OZCELİK, Bekir UCAN, Erkam Sencar

Meme Kanseri Kök Hücreleri ve Demir Bağımlılığı

Ufuk OZER

İnsülinomanin Cerrahi Yönetiminde Uzun Dönem Sonuçlar: Tek Merkez Deneyimi

Orcun YALAV, Gökhan SARITAŞ, Ozgur YAGMUR, Abdullah ULKU, Atılgan Tolga AKCAM, Ahmet RENCUZOGULLARİ, Kubilay DALCI, Ismail Cem ERAY