An Acute Brucellosis Case Presented with Pancytopenia and Hepatitis
Brucellosis is a common zoonotic disease in endemic areas like Turkey. It is an infection that can bemanifested by extensive clinical findings, for this reason it can be difficult to diagnose. In humans,treatment of the disease requires long-lasting combined antibiotics and appropriate treatmentregimens, but it is often difficult to achieve this success in countries with limited resources.Therefore, this may be an important economic burden in terms of both cost of treatment andpotential loss of labor in individuals affected by brucellosis. A 23-year-old male patient who waspresented with fever, pancytopenia and hepatitis, was hospitalized with the aim of investigating theetiology of fever. On laboratory findings supporting the Brusella disease, we started treatment withthe combination of gentamycin and doxycycline to avoid drug-induced hepatotoxic effect. Laboratoryfindings were successfully improved while clinical complaints decreased. Brucella disease should bekept in mind in in endemic areas, concerning patients with abnormal laboratory findings of thehematopoietic or hepatobiliary system. Taking into consideration the side effects of the medicinesused in the treatment of the disease, effective and least toxic combinations should be selected.
Anahtar Kelimeler:
Brucellosis, pancytopenia
___
- 1. Galińska EM, Zagórski J. Brucellosis in humans--etiology, diagnostics, clinical forms. Ann Agric Environ Med. 2013;20:233-8.
- 2. de Glanville WA, Conde-Âlvarez R, Moriyon I, et al. Poor performance of the rapid test for human brucellosis in health facilities in Kenya. PLoS Negl Trop Dis. 2017;11:e0005508.
- 3. Kaya O, Avsar K, Zeynep Akçam F. Unusual manifestations of brucellosis. Arch Med Sci. 2011;7:173- 5.
- 4. Sözen TH. Bruselloz. Willke Topçu A, Söyletir G, Doğanay M (eds): Infeksiyon Hastalıkları ve Mikrobiyolojisi, 3rd edn. İstanbul: Nobel Basımevi 2002;636-42.
- 5. Bakri FG, Al-Bsoul NM, Magableh AY,et al. Brucellosis presenting as myelofibrosis: first case report. Int J Infect Dis. 2010;14:e158-60.
- 6. Sakin A, Çelik K, Öztürk S, et al. Bruselloza bağlı bir febril nötropeni olgusu. Med Bull Haseki 2012;50:69-71.
- 7. Buzgan T, Karahocagil MK, Irmak H, et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis. 2010;14:e469- 78.
- 8. Akdeniz H, Irmak H, Demiröz AP. Evaluation of brucellosis cases in Van region of Eastern Anatolia: a-3 year experience. Nagoya Med J.1998;42:101–10.
- 9. Ozer S, Oltan N, Gencer S. Bruselloz: 33 olgunun değerlendirilmesi. Klimik Derg. 1998;11:82-4.
- 10. Mandell GL, Douglas RG, Bennett JE. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 8th edn. Philadelphia: Churcill Livingstone Elsevier, 2015:2583-2589.
- 11. Keramat F, Hashemi SH. Acute brucellar hepatitis: report of two cases. Avicenna J ClinMicrobInfec. 2015;2:e23908.
- 12. Ulug M, Celen MK, Ayaz C. An unusual presentation of brucello¬sis: acute hepatitis. Braz J Infect Dis. 2010;14:641–2.
- 13. Asef Zadeh M, Allami A, Alavian SM. Acute brucella hepatitis in an urban patient. Hepat Mon. 2009;9:310–3.
- ISSN: 1300-2945
- Yayın Aralığı: Yılda 4 Sayı
- Başlangıç: 1963
- Yayıncı: Cahfer GÜLOĞLU