Hakan AYTAN, Ahmet Cantuğ ÇALIŞKAN, Fazlı DEMİRTÜRK

The effect of maternal ABO blood groups and rhesus status on first trimester biochemical markers

Amaç. İlk trimesterde pregnancy-associated plasma protein-A (PAPP-A) ve serum serbest ß-human chorionic gonadotropin (ß-HCG) düzeylerinin anne kan grubu ve rh durumuyla olan değişimlerinin incelenmesi ve bunların Down sendromuna etkilerinin araştırılması. Yöntem. Birinci trimester tarama yapılan 539 tekiz gebeliği olan kadından kan örnekleri toplandıktan sonra maternal serumdaki PAPP-A ve ß-HCG seviyeleri,değişik ABO ve Rh grupları arasında karşılaştırılmıştır. Bulgular. Her ne kadar ß-HCG MoM değerleri Rh negatif kadınlarda Rh pozitif kontrol grubuna göre artmışsa da PAPP-A ve ß-HCG MoM değerlerinde anlamlı bir değişim olmamıştır.B Rh negatif grupta diğer gruplara göre kombine risk yüksek bulunmuştur. Sonuçlar. Gruplar arası bu bağlantının değerinin kanıtlanması için geniş serili çalışmalara gerek vardır.İlk trimester tarama testlerindeki serum MoM değerlerinin gebe kadının ABO ve Rh durumuna göre düzeltilmesi gereklidir.

İlk trimester biyokimyasal belirteçleri üzerine maternal ABO ve Rh kan gruplarının etkisi

Aim. To explore whether first-trimester levels of pregnancy-associated plasma protein-A (PAPP-A) and serum free ß-human chorionic gonadotrophin (free ß-hCG) vary with maternal blood group and rhesus status and to determine their implications for Down syndrome. Methods. Blood samples were collected from all 539 singleton pregnancies undergoing first-trimester screening. Values of maternal serum PAPP-A and ß-hCG were compared among women with different ABO and Rh groups. Results. Although ß-hCG MoM values were increased in Rh negative women compared with Rh positive controls, PAPP-A and ß-hCG MoM values did not differ significantly. Compared to other groups, the combined risk was higher in B Rh negative group (25%). Conclusions. A larger study is required to establish the validity of this correlation between groups. Corrections in the MoM values of serum analytes used in the first-trimester screening depending on the rhesus and ABO status of the pregnant women may be necessary.

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