Ahmet TAYYAR, Mehmet TAYYAR, Mustafa KULA, Ümmühan ABDÜLREZZAK, Ahter Tanay TAYYAR

Midtrimester amniyotik sıvı leptin ve insülin düzeyleri ile gestasyonel diabetes mellitus ilişkisi

Amaç. Bu çalışmanın amacı midtrimester amniyotik sıvıda leptin ve insülin düzeyleriniinceleyerek bunların daha sonraki dönemde gestasyonel diabetes mellitus gelişen olguları tahminetmede faydalı olup olamayacağını araştırmaktır. Yöntem. Genetik amniyosentezle 16-20 haftalıkgebelerden alınan amniyotik sıvı örneklerinde leptin ve insülin düzeylerini araştırdık. Prospektiftakiplerde gestasyonel diabetes mellitusta gelişen ve sağlıklı gebelik sürdüren hastaları kaydettik.Bulgular. Gestasyonel diabetes mellitus gelişen grupta amniyotik sıvı leptin (17,3 ng/mL) veinsülin (3,4 ng/mL) düzeyleri kontrol grubunun amniyotik sıvı leptin (10,1 ng/mL) ile amniyotiksıvı insülin (1,7 ng/dL) düzeylerine göre istatistiksel olarak yüksek bulunmuştur. Sonuç.Amniyotik sıvıda henüz gestasyonel diabetes mellitus bulguları ortaya çıkmadan leptin ve insülindüzeylerinin yüksek bulunması bu proteinlerin gestasyonel diabetes mellitusu önceden tahminetmede kullanılabileceği kanısını vermektedir.

Midtrimester amniotic f luid leptin and insulin levels and their relation with gestational diabetes mellitus

Aim. The aim of this study is to investigate whether amniotic fluid leptin and insulin levels can beused for prediction of for prediction of gestational diabetes mellitus or not. Methods. The levels ofleptin and insulin were measured in the samples of amniotic fluid which were obtained at 16-20weeks of pregnancy during genetic amniocentesis. We recorded the patients who developedgestational diabetes mellitus and who had healthy gestation. Results. Amniotic fluid leptin (17.3ng/mL) and insulin (3.4 ng/mL) levels were significantly increased in gestational diabetes mellitusgroup as compared to control group s amniotic fluid leptin (10.1 ng/mL) and amniotic fluid insülin(1.7 mg/mL) levels. Conclusion. Increased levels of amniotic fluid leptin and insulin levels beforegestational diabetes mellitus symptoms gives the idea that these proteins can be used as predictorsfor gestational diabetes mellitus.

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