Serdal KORKMAZ, Mübeccel ARSLAN, Özlem YÖNEM, Fatih KILIÇLI, Elvan AMASYALI, Fettah ACIBUCU, Ramazan SAY, Bülent UYGUNGELEN

Metabolik sendromda ürik asit düzeyi ile nonalkolik yağlı karaciğer hastalığı arasındaki ilişki

Amaç. Bu çalışmanın amacı metabolik sendrom (MS) hastalarında non-alkolik yağlı karaciğerhastalığının (NAYKH) sıklığını ve serum ürik asit değeri ile arasındaki ilişkiyi araştırmaktır.Yöntem. Çalışmaya 26sı erkek ve 34ü kadın toplam 60 MS olgusu ile 21i erkek ve 21i kadıntoplam 42 sağlıklı birey alındı. On iki saatlik açlık sonrası alınan kan örneklerinde; açlık kanşekeri (AKŞ), trigliserid, yüksek dansiteli lipoprotein, düşük dansiteli lipoprotein (LDL), ürik asitdüzeyleri ve insülin değerlerine bakıldı. İnsülin direncini belirlemek için HOMA-IR formülükullanıldı. Karaciğer yağlanmasının derecesi ultrasonografik olarak değerlendirildi. Bulgular.Çalışmamızda MS grubundaki ürik asit düzeyleri, kontrol grubu olgularının ürik asitdüzeylerinden istatistiksel olarak anlamlı olacak şekilde yüksekti (p

The relation between serum uric acid levels and nonalcoholic fatty liver disease in metabolic syndrome.

Aim. The purpose of this study is to investigate the frequency of non-alcoholic fatty liver disease(NAFLD) in patients diagnosed as metabolic syndrome (MS) and also to find out its relation withserum uric acid levels. Methods. A total of 60 MS patients (26 male, 34 female) and 42 healthyindividuals (21 male, 21 female) were included in the study. After a fasting period of 12 hours,serum glucose, triglyceride, high density lipoprotein, low density lipoprotein, uric acid and insulinlevels were determined. HOMA-IR formula was used to determine insulin resistance.Ultrasonography was used in showing the grade of hepatosteatosis. Results. Mean serum uric acidlevel of the MS group was significantly higher than the control group in our study (p

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