Derya BÜYÜKKAYHAN, Ali KAYA, Ali ÇETİN, Semra KARA, Fadime YÜKSEL, Ömer CEVİT

Kordon kanı lipid profili, aterosklerotik kalp hastalığı riskini belirler mi ?

Amaç. Hiperkolesterolemi ateroskleroz nedenleri arasında en önemlisidir. Serum lipid bozuklukları çocukluk çağında başlar ve aterosklerotik lezyon yaşamın erken döneminde oluşur. Bu çalışmada, kordon kanı lipid profili ile gestasyonel parametreler, maternal parametreler ve maternal lipid profili karşılaştırıldı. Yöntem. Kordon kanında ve anne serumunda total kolestrol, trigliserit, yüksek dansiteli lipoprotein (YDL), düşük dansiteli lipoprotein, çok düşük dansiteli lipoprotein düzeyleri ölçüldü. Kordon kanı lipid düzeyleri ile bebeğe ait ve anneye ait parametreler arasında ilişki olup olmadığı araştırıldı. Bulgular. Kord kanı lipid düzeyleri yetişkin değerlerinden düşüktü. Kord kanı YDL düzeyi ile maternal YDL düzeyi arasında pozitif yönlü korelasyon vardı (p=0,03). Trigliserit-kolesterol ve YDL dışındaki diğer lipoprotein düzeylerinde, kord ve anne serumu arasında anlamlı bir farklılık saptanmadı (p>0,05). Sonuç. Bu çalışmada kord kanı YDL düzeyinin, ateroskleroz gelişimi belirlemede prediktif değeri olabileceği kanısına ulaşıldı.

The lipid profile of the cord blood can determine the risk of the atheroscleotic cardiovascular disease ?

Aim. Hypercholesterolemia is the most important causes of atherosclerosis. Serum lipid abnormalities begin in childhood and that atherosclerotic lesions emerge early in life. In this study, the lipid profiles of the cord blood in newborns were compared in terms of gestational parameters, maternal parameters, maternal lipid profiles .Method. Plasma total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein and very low density lipoprotein were measured in the cord blood of newborns and in serum of the mothers. The relations between cord plasma lipids values and clinical findings of newborns and their mothers were investigated. Results. Cord blood lipid levels were lower than those in adults. Cord blood HDL levels were correlated positively with maternal HDL levels (r= 0.419, p=0.03). However, there were no significant relations between the triglycerides-cholesterol and other lipoproteins levels in cord and maternal blood (p>0.05). Conclusion. We suggest that cord blood HDL levels have a predictive value in the development of the atherosclerosis in later stages of life.

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