Meryem TİMUÇİN, Fettah ACIBUCU, Duygu OĞUZ ACIBUCU

Insulin autoimmune syndrome associated with the use of thiocolchicoside: A Case report

İnsülin otoimmun sendromu (IAS) hipoglisemi ve insülin kullanmaksızın insülin antikorlarının varlığı ile karakterize nadir bir hastalıktır. Biz tiyokolşikosid kullanımına bağlı IAS tanısı koyduğumuz bir vakayı sunuyoruz. 62 yaşında bayan hasta açlıkta ve p ostprandial hipoglisemi semptomları ile başvurdu. Açlık kan şekeri 47mg/dl ve insülin, C peptid, insülin antikor düzeyi yüksek olarak tesbit edildi. 72 saat uzamış açlık testinde hipoglisemi yaşamadı. Şikayetlerinin başlamasından bir ay öncesinde bir hafta süreyle tiyokolşikosid kullanımı vardı, insülin ve diyabetik ilaç kullanımı yoktu. Hastaya insülin otoimmun sendromu tanısı kondu ve diyet tedavisi önerildi. Hastanın üç ay sonrasında şikayetleri azaldı insülin ve C peptid düzeyi düştü.

Tiyokolşikosid kullanımı ile ilişkili insülin otoimmün sendromu: Bir olgu Sunumu

Insulin autoimmune syndrome (IAS) is a disease characterized by hypoglycemia and insulin antibodies without insulin usage. We report the case of a patient diagnosed with IAS that was associated with the use of thiocolchicoside. A 62-year-old female patient was admitted to our clinic with fasting and postprandial hypoglycemia symptoms. She had a fasting glucose level of 47mg/dl, and high insulin, C-peptide and insulin antibody levels were detected. However, she had no signs of hypoglycemia during a 72 hour fasting test. In addition, the patient had used thiocolchicoside for a week a month prior to the beginning of her symptoms, but she was not taking any insulin or diabetic medications. A diagnosis of IAS was made, and the patient was put on an appropriate diet. Three months following this diagnosis, the patient's comp laints have minimilized, and the insulin and C-peptide levels have decreased.

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