Evaluation of mean platelet volume (MPV) levels in brucellosis patients

Amaç. Bruselloz multisistemik bir enfeksiyon hastalığıdır. Brusellozda akut faz reaktanlarınınartmasına neden olan inflamatuar bir süreç izlenmektedir. Mean platelet volume (MPV) nin bazıhastalıklarda inflamasyonu gösteren bir değer olduğu gösterilmiştir. Bu çalışmada brusellozhastalarının MPV düzeylerini araştırmayı amaçladık. Yöntem. Kırkyedi brusella hastasının MPVdüzeyleri incelendi. Bulgular. Çalışmamıza yaş ortalaması 47,4±14,6 olan, 21 (%44,7) erkek, 26(%55,3) kadın,toplam 47 bruselloz hastası ve yaş ortalaması 45,2±12,3 olan 25 (%53,2) erkek, 22(%46,8) kadından oluşan 47 kişilik kontrol grubu dahil edildi. Tedavi öncesi ve tedavi sonrasıeritrosit sedimentasyon hızı (ESR), MPV, red cell distribution width (RDW), hemoglobin (Hgb),beyaz küre (WBC) değerleri arasında istatistiksel olarak anlamlı farklılık mevcuttu. Tedavi öncesiMPV düzeyleri anlamlı olarak düşüktü. Benzer şekilde tedavi öncesi RDW değerlerinde deanlamlı düşüklük saptandı. Akut ve subakut faz arasında MPV düzeyleri açısından farklılıksaptanmadı. Hepatomegali olan ve olmayan grupta da MPV düzeyleri açısından belirgin bir farkyoktu. Splenomegalisi olan hastaların MPV düzeyleri splenomegalisi olmayan hastalara göre dahadüşük idi. Spearman korelasyonu, STAT (serum tube agglutination test) ve MPV arasında anlamlınegatif bir korelasyon gösterdi. Sonuç. MPV düzeyleri bruselloz hastalarının takibinde kullanışlıbir tetkik olabilir.

Bruselloz hastalarında ortalama trombosit hacmi (MP V) düzeylerinin değerlendirilmesi

Aim. Brucellosis is a multisystemic infectious disease. An inflammatory process occurs inbrucellosis which causes increase in acute phase reactants. Mean platelet volume (MPV) has beenshown as an inflammatory marker in some diseases. In this study we searched the MPV levels ofbrucellosis patients. Method. MPV levels of forty-seven patients with brucellosis were evaluated.Results. We included a total of 47 brucellosis patients having an average age of 47.4±14.6 and sexdistribution of 21 (44,7%) male and 26 (55,3%) female and also 47 control healthy subjects havingan average age of 45,2±12,3 and sex distribution of 25 (53,2%) male and 22 (46,8%) female).Erythrocte sedimentation rate (ESR), MPV, red cell distribution width (RDW), Hemoglobin (Hgb)and white blood cell(WBC) values in pre-treatment stage were statistically different from aftertreatment period. MPV levels were significantly lower in the pretreatment group. Similarly RDWvalues were lower in pretreatment group. MPV levels of patients were not diffrent in the acute andsubacute stage. There was not any significant difference in the MPV levels of patients withhepatomegaly and without hepatomegaly (MPV levels of patients with splenomegaly were lowerthan patients without splenomegaly Spearman s correlation analysis showed a significant negativecorrelation between STAT (serum tube agglutination test) and MPV values. Conclusion. MPVlevels may be useful in the follow-up of brucellosis patients

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