Angiopoietin-related growth factor level in preeclampsia
Amaç. Angiopoietin-ilişkili büyüme faktörü anjiogenez ile ilişkilidir fakat glukoz ve enerjimetabolizmasınıda etkileyebilmektedir. Bu çalışmanın amacı preeklampside Angiopoietin-ilişkilibüyüme faktörünün serum seviyelerinin belirlenmesidir. Yöntem. Çalışma 32 preeklampsili kadın(preeklampsi grubu) ve 32 sağlıklı 3. trimesterde gebe kadın (Kontrol grubu) ile yapıldı. Tümolgularda, Angiopoietin-ilişkili büyüme faktörünün serum seviyeleri ile birlikte diğerbiyokimyasal ve antropometrik veriler analiz edildi. Bulgular. Preeklampsili olgulardaAngiopoietin-ilişkili büyüme faktörünün serum seviyeleri (98,6ng/mL) kontrol grubundan (52,2ng/mL) anlamlı yüksekti (p-değeri
Preeklampside Angiopoietin-ilişkili büyüme faktör seviyesi
Aim. Angiopoietin-related growth factor (AGF) is associated with angiogenesis but it can alsoaffect glucose and energy metabolism. The aim of this study was to determine AGF levels inpreeclampsia. Method. The study included 32 women with preeclampsia (preeclampsia group)and 32 non-preeclamptic, healthy, third trimester pregnant women (Control group). We analyzedserum levels of AGF and other biochemical and anthropometric markers in all subjects. Results.Serum AGF levels were significantly higher in subjects with preeclampsia (98.6 ng/mL) than thosein the control group (52.2 ng/mL), (p-value
___
- 1. Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy 2001; 20: IX-XIV.
- 2. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005; 365: 785-99.
- 3. Verlohren S, Stepan H, Dechend R. Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia. Clin Sci (Lond) 2012; 122: 43-52.
- 4. Oike Y, Tabata M. Angiopoietin-like proteins--potential therapeutic targets for metabolic syndrome and cardiovascular disease. Circ J 2009; 73: 2192-7.
- 5. Oike Y, Yasunaga K, Suda T. Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis. Int J Hematol 2004; 80: 21-8.
- 6. Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med 2005; 11: 400-8.
- 7. Kadomatsu T, Tabata M, Oike Y. Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases. FEBS J 2011; 278: 559- 64.
- 8. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183: S1-S22.
- 9. Radikova Z, Koska J, Huckova M, Ksinantova L, Imrich R, Vigas M, Trnovec T, Langer P, Sebokova E, Klimes I. Insulin sensitivity indices: a proposal of cut-off points for simple identification of insulin-resistant subjects. Exp Clin Endocrinol Diabetes 2006; 114: 249-56.
- 10. Oike Y, Ito Y, Maekawa H, Morisada T, Kubota Y, Akao M, Urano T, Yasunaga K, Suda T. Angiopoietin-related growth factor (AGF) promotes angiogenesis. Blood 2004; 103: 3760-5.
- 11. Oike Y, Yasunaga K, Ito Y, Matsumoto S, Maekawa H, Morisada T, Arai F, Nakagata N, Takeya M, Masuho Y, Suda T. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Proc Natl Acad Sci USA 2003; 100: 9494-9.
- 12. Stepan H, Ebert T, Schrey S, Reisenbüchler C, Stein S, Lossner U, Bluher M, Stumvoll M, Kratzsch J, Faber R, Fasshauer M. Serum levels of angiopoietin- related growth factor are increased in preeclampsia. Am J Hypertens 2009; 22: 314-8.
- 13. Stepan H, Unversucht A, Wessel N, Faber R. Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion. Hypertension 2007; 49: 818-24.
- 14. Namkung J, Koh SB, Kong ID, Choi JW, Yeh BI. Serum levels of angiopoietin- related growth factor are increased in metabolic syndrome. Metabolism 2011; 60: 564-8.