(1R, 2R) -1,2-BIS- (5- (4-Hidroksinaftalin-1- İlazo) - [1, 3,4] Tiyadiazol-2-Diol Yeni Bileşiğinin İn vitro Antioksidan Özellikleri

1,3,4-Tiyadiazoller yapılarındaki gruplara bağlı olarak çeşitli biyolojik aktivitelere sahiptir. Bu çalışma, (1R,2R) -l, 2-bis- (5- (4-hidroksinaftalin-1-ilazo) - [l, 3,4] tiyaiyazol-2-il) etan-1,2-diole yeni bileşiğinin in vitro antioksidan özelliklerini araştırmayı amaçlamaktadır. Bu çalışmada antioksidan aktiviteler; DPPH. radikal temizleme aktivitesi, demir azaltma gücü kapasitesi, metal şelatlama aktivitesi ve hidroksil radikali temizleme aktivitesi gibi farklı yöntemlerle ölçüldü Sonuç olarak, bu yeni bileşiğin BHT ve α -tokoferol gibi referans antioksidanlar ile karşılaştırıldığında etkili antioksidan ve serbest radikal süpürücü aktiviteye sahip olduğu belirlendi.

In vıtro Antioxidant Properties of Novel Compound (1R, 2R) -1,2-bis- (5- (4-Hydroxynaphthalen-1-ylazo) - [1,3,4] Thiadiazol-2-YL) -Ethane- 1,2-Diole

1,3,4-Thiadiazoles have a variety of biological activities depending on their substituents. This study aims to investigate the in vitro antioxidant properties of 1R,2R -1,2-bis- (5- (4-hydroxynaphthalen-1-ylazo) - [1,3,4] thiadiazol-2-yl) -ethane- 1,2-diole novel compound. In this study, antioxidant activities were measured by different methods such as, DPPH. radical scavenging activity, iron reducing power capacity, metal chelating activity and hydroxyl radical scavenging activity. As a result, it was determined that this new compound has effective antioxidant and free radical scavenging activity when compared to reference antioxidants such as BHT and α-tocopherol.

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Cumhuriyet Science Journal-Cover
  • ISSN: 2587-2680
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2002
  • Yayıncı: SİVAS CUMHURİYET ÜNİVERSİTESİ > FEN FAKÜLTESİ
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