İntrakraniyal kanamalı 36 vakanın retrospektif olarak değerlendirilmesi
AMAÇ: intrakraniyal kanaması olan olgularımızın klinik ve laboratuvar bulgularını retrospektif olarak gözden geçirmek ve literatür ile karşılaştırmak. GEREÇ ve YÖNTEM: Çukurova Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Yoğun Bakım Ünitesi ve servisinde, yatarak izlenen, yaşları 1 ay ile 14 yaş arasında değişen 36 intrakraniyal kanama olgusu retrospektif olarak incelendi. BULGULAR: Çalışmaya alman olguların 23'ü (%63.9) erkek ve 13'ü (%36.1) kız İdi. Hastanemize başvuruları sırasındaki başlıca yakınmaları; konvülsiyon (%61.1), fışkırır tarzda kusma (%50.0) ve huzursuzluk (%36.1) idi. Etyolojide en sık olarak yenidoğanın geç hemorajik hastalığı (%55.6) ve travma (%22.2) saptandı, intrakraniyal kanamanın lokalizasyonu olarak en sık subdural hematom (%72.2) saptandı. SONUÇ: Çocukluk çağında intrakraniyal kanamalar bir çok nedene bağlı olarak gelişebilmekte, tanının erken konması, etyolojik nedenin erken saptanması ve erken dönemde tedavi ile morbidite ve mortalite oranlarının düşürülmesi mümkün olabilir. Ayrıca, her yenidoğana K vitamini yapılması, çocukların kanamadan korunmaları sağlayacaktır.
The retrospective evaluation of thirty-six cases of intracranial hemorrhages
PURPOSE: Retrospective review of the cases with intracranial hemorrhage regarding clinical, laboratory, and etiological features and its comparison with literature. METHODS: Thirty six patients with intracranial hemorrhage who were hospitalized at Çukurova University, in the pediatrics units and PICU and whose ages ranging from 1 month to 14 years were enrolled to the study. RESULTS: Of all cases, 23 (63.9%) were male whereas 13 (36.1%) were female. At admission, their main manifestation were convulsion (61.1%), vomiting (50.0%), irritability (36.1%). Late hemorrhagic disease of the newborn (55.6%) and trauma (22.2%) were the most frequent seen causes. The most common involvement was subdural hematoma (72.2%). CONCLUSION: During childhood, intracranial hemorrhages can be developed as a result of many causes. By early diagnosis, prompt detection of the etiologic factors, and immediate and appropiate treatment, it is possible to reduce the rate of morbidity and mortality.
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- 1. Aoki N, Masuzawa H. Infantile acute subdural hematoma: clinical analysis of 26 cases. J Neurosurg 1980; 61: 273-280.
- 2. Arya LS, Jain Y, Narain S. Spontaneous intracranial hemorrhage in children with immune thrombocytopenic purpura. Indian Pediatr 2002; 39: 468-472.
- 3. Bör Ö, Akgün N, Sarhuş F, et al. Late hemorrhagic disease of the newborn. Pediatr Int 2000; 42: 64-66.
- 4. de Tezanos Pinto M, Fernandez J, Perez Bianco PR. Update of 156 episodes of central nervous system bleeding in hemophiliacs. Haemostasis 1992; 22: 259-267.
- 5. Di Rocco C, Tamburrini G, Rollo G. Cerebral arteriovenous malformations in children. Acta Neurochir 2000; 142: 145-148.
- 6. Erdem G, Vanderford PA, Bart RD. Intracranial hemorrhage in herpes simplex encephalitis: an unusual presentation. Pediatr Neurol 2002; 27: 221-223.
- 7. Fenichel GM. Altered states of consciousness. In: Clinical Pediatric Neurology: a signs and symptoms approach (3rd.ed). Philadelphia, 1997, p47-77.
- 8. Fritschi JA, Reulen HJ, Spetzler RF, et al. Cavernous malformations of the brain stem. A review of 139 cases. Acta Neurochir 1994; 130: 35-46.
- 9. Fukazawa K, Nagao T, Kuwana N, et al. Aplastic anemia with antiplatelet iso-antibody and intracerebral hemorrhage: a cse report of a child treated by platelet transfusion, splenectomy and craniotomy. Rinsho Ketsueki 1980; 21: 1761-1766.
- 10. Gilles EE, Nelson MD. Cerebral complications of nonaccidental head injury in childhood. Pediatr Neurol 1998; 19: 119-128.
- 11. Hoyer LW. Hemophilia A. N Engl J Med 1994; 330: 38-47.
- 12. Humpl T, Bruhl K, Bohl J, et al. Cerebral hemorrhage in long-term sırvivors of childhood acute lymphoblastic leukemia. Eur J Pediatr 1997; 156: 367-370.
- 13. Karpaktin S: Autoimmune thrombocytopenic purpura. Semin Hematol 1985; 22: 260-288.
- 14. Kieslich M, Porto L, Lanfermann H, et al. Cerebrovascular complications of L-asparaginase in the theraphy of acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2003; 25: 484-487.
- 15. Lane PA, Hathaway WE. Vitamin K in infancy. J Pediatr 1985; 106: 351-359.
- 16. Lewis DW, Qureshi F. Acute headhace in children and adolescents presenting to the emergency departmant. Headhace 2000; 40: 200-203.
- 17. Lin CL, Loh JK, Kwan AL, et al: Spontaneous intracerebral hemorrhage in children. J Med Sci 1999; 15: 146-151.
- 18. Loh JK, Lin CL, Howng SL. Acute subdural hematoma in infancy. Surg Neurol 2002; 58: 218-224.
- 19. McGrath N, Anderson NE, Craxson MC. Herpes simplex encephalitis treated with acyclovir: diagnosis and long-term outcome. J Neurol Neurosurg Psychatry 1997; 63: 321-326.
- 20. Medeiros D, Guilburd GR. Current contro-versies in the management of idiopathic thrombocytopenic purpura during childhood. Pediatr Clin North Am 1996; 43: 757-772.
- 21. Packer RJ, Rorke LB, Lange BJ, et al. Cerebrovascular accidents in children with cancer. Pediatrics 1985; 76: 194-201.
- 22. Sauerbrei A, Eichhorn U, Hottenrott G, et al. Virological diagnosis of herpes simplex encephalitis. J Clin Virol 2000; 17: 31-36.
- 23. Singh M: Vitamin K during infancy: current status and recommendations. Indian Pediatr 1997; 34: 708-712.
- 24. Spetzler RF, Hargraves RW, Mc Cormick PW. Relation-ship of pressure and size to risk of hemorrhage from arteriovenous malformations: J Neurosurgery 1992; 76: 918-923.
- 25. Stojimirovic E, Cvetkovic P, Baklaja R, et al. Wiskott-Aldrich syndrome. Bilt Hematol Transfuz 1977; 5: 67-71.
- 26. Sutar AH. Vitamin K deficiency bleeding in infants and children. Semin Thromb Hemost 1995; 21: 317-329.
- 27. Urban C, Sager WD. Intracranial bleeding during theraphy with L-asparaginase in childhood acute lymphocytic leukemia. Eur J Pediatr 1981; 137: 323-327.
- 28. Vitamin K Ad Hoc Task Force, American Academy of Pediatrics: Controversies concerning vitamin K and the newborn. Pediatrics 1993; 91: 1001-1003.
- 29. Wells RG, Vetter C, Laud P. Intracranial hemorrhage in children younger than 3 years. Arch Pediatr Adolesc Med 2002; 156: 252-257.
- 30. Yamasaki M, Akagi K, Niinomi K, et al. Intracranial hemorrhage associated with aplastic anemia. No To Hattatsu 1989; 21: 215-221.