Özgür KARTAL, Abdullah BAYSAN, Osman ŞENER, Uğur MUSABAK, Nail ERSÖZ, Mustafa GÜLEÇ, Ahmet Zafer ÇALIŞKANER, Şevket ARSLAN

Hereditary angioedema may not be the only cause of abdominal pain in patients with hereditary angioedema!

Herediter anjioödemin temel klinik presentasyonlarından birisi karın ağrısıdır. Danazol herediter anjioödem hastalarında uzun yıllar yaygın olarak kullanılmış olan bir ilaçtır. Burada nihai tanıları kolon karsinomu olan danazol tedavisi altında karın ağrısı olan iki herediter anjioödem hastası sunulmuştur. Bu makalede 2 konu vurgulanmıştır. Birincisi; herediter anjioödem hastalarında ''karın ağrısı'' ayırıcı tanısının, herediter anjioödem tanısı mevcut olsa bile yapılması gereken bir semptom olma özelliğini koruduğunu vurgulamak; ikincisi ise uzun süreli uygulanan danazol tedavisinin maligniteler gibi olası bir advers etkisini ortaya koymaktır

Herediter anjioödemli hastalarda karın ağrısının tek nedeni herediter anjioödem olmayabilir

Abdominal pain is one of the basic clinical presentations of the hereditary angioedema and danazol is a common medicine which has been used for long years in patients with hereditary angioedema. We present two hereditary angioedema patients with abdominal pain albeit under danazol treatment, whose final diagnoses was colon carcinoma. There are two consequences in this article which shall be insisted on: First; in patients with hereditary angioedema, the differential diagnosis of "abdominal pain" is always important even though hereditary angioedema diagnosis exists. And the second; It can be hardy speculated that long term danazol treatment may cause different malignancies

PDF

___

Riguzzi C, Losonczy L, Teismann N, Herring AA, Nagdev A. Gastrointestinal manifestations of hereditary angioedema diagnosed by ultrasound in the emergency department. West J Emerg Med. 2014;15:816-8.
Khan DA. Hereditary angioedema: Historical aspects, classification, pathophysiology, clinical presentation, and laboratory diagnosis. Allergy Asthma Pro. 2011;32:1-10.
Xu YY, Buyantseva LV, Agarwal NS, Olivieri K, Zhi YX, Craig TJ. Update on treatment of hereditary angioedema. Clin Exp Allergy. 2013;43:395-405.
Nzeako UC, Longhurst HJ. Many faces of angioedema: focus on the diagnosis and management of abdominal manifestations of hereditary angioedema. Eur J Gastroenterol Hepatol. 2012;24:353-61.
Rosen FS, Austen KF. Androgen therapy in hereditary angioneurotic edema. N Engl J Med. 1976;295:1476-7.
Bork K. Current management options for hereditary angioedema. Curr Allergy Asthma Rep. 2012;12:273- 80.
Berkel AE, Bouman DE, Schaafsma MR, Verhoef C, Klaase JM. Hepatocellular carcinoma after danazol treatment for hereditary angio-oedema. Neth J Med. 2014;72:380-2.