Baş boyun bölgesi kanserlerinde histopatolojik özelliklerin ve angiogenezisin prognozdaki önemi
Ç.Ü. T.F. Radyasyon Onkolojisi Anabilim Dalında tedavi edilmiş bas boyun bölgesi epidermoid kanserli 81 olguda prognozu etkileyen klinik ve histopatolojik parametreler değerlendirildi. Olguların %26.5'i erken, %73.5'i ileri evre grubundaydı. Keratinizasyon oranı, mitoz sayısı, nükleer grade, invazyon paterni, invazyon derinliği, tümör etrafındaki plazmositik lenfositik infiltrasyon cevabı ve lenfatik-vasküler invazyon varlığına göre histopatolojik değerlendirme yapıldı. İnvazyon tipi ile bölgesel lenfatik tutulum arasında anlamlı ilişki bulundu(p
The effect of histopathological factors and angiogenesis on prognosis of head and neck cancers
From 1990 through 1996 eighty one epidermoid head and neck cancer cases treated with external radiotherapy analyzed. Histopathological and clinical factors affecting prognosis were reported. The carcinomas were evaluated using modification of the criteria outlined by Jakobsson. In an attempt to quantities cytoplasmic keratinization, nuclear differentiation, frequency of mitoses, inflammatory cell response, stage of invasion, pattern of invasion and vascular invasion We assign to each observation a point score that ranges from 1 to 4. Each of the tumor parameter compared with radioresponce and survival The pattern of invasion correlate with regional lymphatic metastasis Early stage (stage I-II) ratio was 26.5%, advanced stage (stage III-IV) ratio was 73.5%. Multivariate analysis showed that the stage of disease are the most significant and independent predictors for prognosis To determine angiogenesis correlates with prognosis in head and neck cancers, we counted micro vessels within the epidermoid carcinomas Microvessels were highlighted by factor VIII related antigen. Microvessels were counted in a X400 field in the most active areas of neovascularization. The mean microvessel count in all tumors 25.2 (median 26). The counts within carcinomas from patients without lymphatic metastasis were significantly lower20 from patients with lymphatic metastasis27. Multivariate analysis showed that both stage and nuclear differentiation but not microvessel density are significant and independent predictors of prognosis.