Electrospun Nanofibröz Matlardan Ampisilin Salımının Sayısal Analizi

Elektrospun nanofibröz mat, ilaç salım çalışmaları için güncel bir tekniktir. Bu nedenle, mevcut sorunların üstesinden gelmek ve yeni ilaç salım sistemleri oluşturmak için bu tür sistemlerin ilaç salım davranışını incelemek önemlidir. Bu makalede, bu gerekliliğin karşılanması için sayısal bir çalışma yapılmış ve mevcut sayısal veriler literatürde bulunan deneysel çalışma sonuçları ile doğrulanmıştır. Geçici Langmuir-Freundlich adsorpsiyon-desorpsiyon izotermi, elektrospun nanofibröz sistemin mükemmel kuyu koşulları altında ilaç salım davranışını açıklamak için kullanılmıştır. Difüzyonun etkisi de hesaba katılmıştır. İlaç salım oranları, farklı ilk ilaç konsantrasyonları, gözenek değerleri, geçirgenlik kütle katsayıları ve mat yüzey alanları için araştırılmıştır. Ayrıca gözenek ve ilk ilaç konsantrasyonu arasındaki ilişki de bu çalışmada verilmiştir. Çeşitli başlangıç ilaç konsantrasyonları ve gözenekler vasıtasıyla ilaç salım oranlarında bazı önemli değişikliklerin meydana geldiği görülmüştür. İlaç salım hızı, geçirgenlik katsayısı veya yüzey alanı ile değişmekle birlikte, bu değişimlerde yukarıda bahsedilen parametrelere göre küçük farklılıklar gözlenmektedir. Sayısal kodun sonuçları deneysel verilerle uyumludur.

Anahtar Kelimeler:

Kontrollü ilaç salımı, Elektrospinning, Nanofibröz mat, Sayısal analiz, Adsorpsiyondesorpsiyon kinetiği

Numerical Analysis of Ampicillin Release from Electrospun Nanofibrous Mats

The electrospun nanofibrous mat is an emerging tool for drug release studies. Therefore, it is essential to predict this type of system's drug release behavior to overcome the existing problems and generate novel drug release systems. In the present work, a numerical study is performed for fulfilling this requirement, and the current numerical data is validated with the experimental study, which is available in the open literature. Transient Langmuir-Freundlich adsorption-desorption isotherm is employed for describing the drug release behavior of the electrospun nanofibrous system under perfect sink conditions. The effect of the diffusion phenomenon is also taken into account. Drug release rates are investigated for different initial drug concentrations, porosity values, permittivity mass coefficients, and mat surface areas. Moreover, the relationship between the porosity and the initial drug concentration is also presented. It can be reported that significant alterations occur in drug release rates through varied initial drug concentrations and porosity. Although the drug release rate is altered with permittivity coefficient or surface area, minor variations are observed compared to the parameters above. The results of the numerical code agree well with the experimental data.

Keywords:

Controlled drug release, Electrospinning, Nanofibrous mat, Numerical analysis, Adsorption-desorption kinetics,

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