Yalçın AVCI, Ali Rıza DEMİR, Arda GÜLER, Tugba AKTEMUR, Serkan KAHRAMAN, Begüm UYGUR, Gökhan DEMİRCİ, Enes ARSLAN, Ahmet Emir ULUTAŞ, Mehmet ERTURK

Trigliserit-glikoz indeksi ST-segment yükselmeli miyokard enfarktüslü hastalarda rezidüel SYNTAX skoru ile ilişkilidir

Amaç: Trigliserit-glukoz indeksi (TyG) insülin direncini yansıtan önemli bir parametredir ve son yıllarda kullanımı artmıştır. Kardiyovasküler hastalıklarla ilişkisi daha önceki çalışmalarda gösterilmiştir. Amacımız, primer perkütan koroner girişim uygulanan ST segment yükselmeli miyokard enfarktüsü (STEMI) hastalarında rezidüel SYNTAX skorunun (rSS) TyG indeksi ile ilişkisini araştırmaktır. Gereç ve Yöntem: Çalışmaya primer perkütan koroner girişim uygulanan toplam 663 STEMI hastası dahil edildi. Hastalar, TyG indeks düzeyine göre yüksek ve düşük olmak üzere iki gruba ayrıldı. TyG indeksi için cut-off değeri ROC analizi ile 9,61 olarak belirlendi. Başlangıç klinik ve demografik değişkenlerin yanı sıra koroner arter hastalığı şiddeti her iki grup için de hesaplandı. Bulgular: Yüksek TyG indeksi grubunda 281 hasta ve düşük TyG indeksi grubunda 386 hasta değerlendirildi. 8'in üzerindeki rSS, yüksek olarak kabul edildi. Artmış TyG indeksi grubunda yüksek rSS olan hastaların oranı diğer gruba göre anlamlı derecede yüksek bulundu [114 (40.6) vs. 54 (14.0]. Ek olarak, lojistik regresyon analizinde daha yüksek TyG indeksi, daha yüksek rSS’nin bağımsız öngörücüsü olarak belirlenir. Sonuç: Yüksek TyG indeksi, rSS ile güçlü bir ilişkiye sahiptir ve daha yüksek TyG indeksi, STEMI hastalarında artan rSS'nin bağımsız bir öngördürücüsüdür.

Anahtar Kelimeler:

Trigliserid- glukoz indeksi, St yükselmeli miyokart enfarktüsü, rezidüel SYNTAX skoru

Triglyceride-glucose index is associated with residual SYNTAX score in patients with ST-segment elevation myocardial infarction

Purpose: The triglyceride-glucose index (TyG) is an important parameter that reflects insulin resistance and its use has increased recently. Its relationship with cardiovascular diseases has been shown in previous studies. Our aim was to investigate the association of residual SYNTAX score (rSS) with TyG index in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Materials and Methods: A total of 663 STEMI patients who underwent primary percutaneous coronary intervention were included in the study. The patients were divided into 2 groups according to the TyG index level as high and low. The cut-off value for the TyG index was determined as 9.61 by ROC analysis. Coronary artery disease severity was calculated for both groups besides baseline clinical and demographic variables. Results: A total of 281 patients were evaluated in the high TyG index group and 386 patients in the low TyG index group. A rSS above 8 was considered high. The proportion of patients with high rSS in the increased TyG index group was found to be significantly higher than in the other group [114 (40.6) vs. 54 (14.0)]. In addition, higher TyG index is determined to be the independent predictor of higher rSS in logistic regression analysis. Conclusion: High TyG index had a strong association with rSS and higher TyG index was an independent predictor of increased rSS in patients with STEMI

Keywords:

Triglyceride-glucose index, ST elevation myocardial infarction, residual SYNTAX score,

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