Burcu BEKSAC, Hanife Guler DONMEZ, Murat CAGAN, M.sinan BEKSAC

Kötü obstetrik öyküsü ve deri hastalıkları olan kadınlarda anti-parietal hücre antikor pozitifliği: gebelik öncesi danışmanlığın önemi

Amaç: BU çalışmanın amacı kötü obstetrik öyküsü ve deri hastalıkları olan kadınlarda anti-parietal hücre antikor (APCA) pozitifliğinin anlamını göstermektir. Gereç ve Yöntem: Bu retrospektif kohort, deri hastalıkları ve kötü obstetrik geçmişi olan 63 kadından oluşuyordu. Hastalar kontrol (sadece deri hastalıkları olan kadınlar, n=50) ve çalışma grubu (deri hastalıkları ve APCA pozitifliği olan kadınlar, n=13) olarak gruplandırılmıştır. Çalışma ve kontrol grubu demografik bulgular, BOI ve plasentaya bağlı obstetrik komplikasyonlarla ilişkili risk faktörleri açısından karşılaştırıldı. Bulgular: APCA (+) ve APCA (–) grupları; yaş, gravida, parite, BOI ve düşük sayısı gibi demografik bulgular açısından istatistiksel olarak anlamlı farklılık göstermedi. APCA (+) vakaların %69,2'sinin (9/13) iki veya daha fazla deri hastalığına sahip olduğunu, ancak bu oranın APCA (-) olanlarda %34 bulunduğunu gösterdik. APCA (+) ve APCA (–) grupları arasında tekli ve çoklu deri hastalığı varlığı açısından istatistiksel olarak anlamlı fark vardı. APCA (+) ve APCA (-) hastalar arasında obstetrik komplikasyonlarla ilişkili risk faktörlerinin (bağışıklık sistemi sorunları, MTHFR polimorfizmleri, kalıtsal trombofili ve diyabetes mellitus tip-2 gibi) varlığı açısından istatistiksel olarak anlamlı bir farklılık gösteremedik. Sonuç: Obstetrik komplikasyonlar için risk faktörü olan APCA pozitifliğinin, gebelik öncesi danışma sırasında belirlenmesi, kötü obstetrik öykü ve dermatolojik sorunları olan hastalarda çoklu deri hastalıklarının önceden belirlenmesinde önemli rol oynayabilir.

Anahtar Kelimeler:

Anti-Parietal Antikor, Cilt Bozukluğu, Kötü Obstetrik Öykü, Gebelik öncesi danışmanlık

Anti-parietal cell antibody positivity in women with poor obstetric history and skin disorders: significance of preconception counseling

Purpose: The aim of this study was vto demonstrate the impact of anti-parietal cell antibody (APCA) positivity in women with poor obstetric history and skin disorders. Materials and Methods: This retrospective cohort consisted of 63 women having skin disorders and poor obstetric history. Patients were grouped into the control (women with skin disorders only, n=50) and study groups (women with skin disorders and APCA positivity, n=13). The study groups were compared in terms of demographic findings, BOI, and risk factors for placenta-related obstetric complications. Results: APCA (+) and APCA (–) groups showed no statistically significant difference in terms of demographic findings such as age, gravidity, parity, BOI, and the number of miscarriages.. We have demonstrated that 69.2% (9/13) of the APCA (+) cases have two or more skin diseases, while 34% of APCA (-) women have multiple skin diseases. There was a statistically significant difference between APCA (+) and APCA (–) groups in terms of the presence of single or multiple skin diseases (p=0.029). We could not demonstrate a statistically significant difference between APCA (+) and APCA (–) patients in terms of the presence of risk factors for obstetric complications such as immune system problems, MTHFR polymorphisms, hereditary thrombophilia, and diabetes mellitus type-2. Conclusion: APCA positivity which is a risk factor for obstetric complications might be a good indicator used to identify susceptibility to multiple skin disorders during preconception counseling.

Keywords:

Anti-parietal antibody, skin disorders, poor obstetric history, preconception counseling,

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