Zeynep KUNT, Gamze MADEN, Mehmet Egemen KARATAŞ, Gülay MART

Tiroid bozukluğu olan hastalarda optik koherens tomografi ile elde edilen optik disk, makula ve gangliyon hücre tabakası ölçümleri

Amaç: Bu çalışmanın amacı tiroid hastaları ile yaş ve cinsiyet uyumlu sağlıklı kontrol grubu arasında retina sinir tabakası kalınlıkları, santral makula kalınlığı ve gangliyon hücre tabakası ölçümlerini optik koherens tomografi (OKT) kullanarak karşılaştırmaktır. Gereç ve Yöntem: Tiroid hasta grubuna 80 hastanın 80 gözü ve kontrol grubun 48 hastanın 48 gözü çalışmaya alındı. Dışlama kriterleri değerlendirildikten sonra çalışmaya alınan tüm hastalara görme keskinliği, ön segment biyomikroskopisi, göz içi basıncı, fundoskopi ve spectral field optik kohorens tomografi (SF-OKT) görüntüleme tetkikleri uygulandı. Bu veriler kaydedildi. Santral maküla kalınlığı (SMK), retina sinir lifi tabakası (RSLT) ve gangliyon hücre kompleksi (GHK) ölçümleri her iki grup için istatistiksel yöntemlerle değerlendirildi. Bulgular: Çalışmaya dahil edilen grupların demografik verileri arasında istatistiksel olarak anlamlı fark saptanmadı. GİB ölçümleri hasta grubunda kontrol grubuna göre istatistiksel olarak anlamlı yüksek tespit edildi. SMK değerleri hasta grubunda 258,2±16,1 µm, kontrol grubunda 273,1±23,8 µm olarak saptandı ve gruplar arası istatistiksel olarak anlamlı fark gözlendi. GHK değerleri ve temporal kadran RSLT değerleri gruplar arasında istatistiksel olarak anlamlı fark gözlendi. Sonuç: Bulgular TO hastalarında sağlıklı kontrol grubuna göre görme kayıplarından önce optik sinir ve makulada değişiklikler geliştiğini desteklemektedir. TO hastalarında fonksiyonel bozulmadan önce yapısal değişiklikler geliştiğinden noninvaziv bir test olan OKT yi klinik pratiğimize ekleyerek TO hastalarını daha objektif ve güvenilir bir şekilde takip edebilir ve tedavi planlamasını daha doğru yapabiliriz.

Anahtar Kelimeler:

gangliyon hücre tabakası, tiroid hastalığı, optik koherens tomografi, Ganglion cell complex, thyroid disease, optical coherence tomography

Optic disc, macula and ganglion cell layer measurements obtained with optical coherence tomography in patients with thyroid disorder

Purpose: The aim of this study was to compare retinal nerve layer thickness, central macula thickness and ganglion cell layer measurements using optical coherence tomography (OCT) between thyroid patients and age- and sex-matched healthy controls. Materials and Methods: Eighty eyes of 80 patients in the thyroid patient group and 48 eyes of 48 patients in the control group were included in the study. After evaluating the exclusion criteria, visual acuity, anterior segment biomicroscopy, intraocular pressure, fundoscopy and spectral field optic coherence tomography (SF-OCT) imaging tests were performed on all patients included in the study. These data have been recorded. Central macular thickness (CMT), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) measurements were evaluated by statistical methods for both groups. Results: There was no statistically significant difference between the demographic data of the groups included in the study. IOP measurements were found to be statistically significantly higher in the patient group compared to the control group. CMT values were 258.2±16.1 µm in the patient group and 273.1±23.8 µm in the control group, and statistically significant differences were observed between the groups. Conclusion: The findings supports that changes in the optic nerve and macula develop before vision loss in TO patients compared to the healthy control group. We can follow TO patients more objectively and reliably and make treatment planning more accurately by adding OCT, which is a noninvasive test, to our clinical practice, since structural changes develop before functional deterioration in TO patients.

Keywords:

Ganglion cell complex, thyroid disease, optical coherence tomography,

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