Ozge GONUL ONER, Ozlem TOTUK, İpek GUNGOR DOGAN, Didem CELİK, Serkan DEMİR

Multipl skleroz hastalarında nöropsikiyatrik bulguların incelenmesi

Amaç: Bu çalışmanın amacı; multipl skleroz (MS) hastalarında apati ve emosyonel labilite gibi nöropsikiyatrik semptomları ve bunların eşlik eden diğer faktörlerle ilişkisini kapsamlı bir şekilde değerlendirmektir. Gereç ve Yöntem: 258 MS hastasına Montreal bilişsel değerlendirme (MoCA), Apati değerlendirme ölçeği (AES), Yorgunluk şiddeti ölçeği (FSS), Emosyonel Labilite (CNS-LS), Beck Depresyon Envanteri (BDI) uygulandı. Ölçekler ve diğer olası nedenler arasında korelasyon ve regresyon analizleri yapıldı. Bulgular: Hastaların %53,6'sında emosyonel labilite, %76.2'sinde yorgunluk mevcuttu. Emosyonel labilite ile yorgunluk ve depresyon arasında pozitif korelasyon izlenirken, apati ile emosyonel labilite ve yorgunluk arasında negatif korelasyon saptandı. Ek olarak, apati ve depresyon arasında negatif korelasyon izlendi. Bilişsel bozukluk ile depresyon ve/veya hastalık süresi ve/veya diğer ölçek puanları arasında ilişki yoktu. Sonuç: Emosyonel labilite ve apati, MS hastalarında oldukça sık görülen ve birbiriyle kesişen/karışan sorunlardır. Buna ek olarak; apati, MS hastalarında ortaya çıkan bağımsız bir nöropsikiyatrik semptom olabilir.

Anahtar Kelimeler:

MS, apati, psödobulbar etkiler

Evaluation of neuropsychiatric symptoms in patients with multiple sclerosis

Purpose: The aim of this study was to comprehensively assess the neurophyschiatric symptoms of multiple sclerosis (MS) such as apathy and pseudobulbar affect and their correlation with other concomitant factors. Materials and Methods: Montreal Cognitive Assessment (MoCA), Apathy Evaluation Scale (AES), Fatigue severity scale (FSS), Center for Neurologic Study-Lability Scale (CNS-LS), Beck Depression Inventory (BDI) are applied to 258 MS patients. Correlation and regression analysis are conducted between scales and other possible causers. Results: 53.6% of the patients have psuedobulbar affect, 76.2% of patient population have fatigue. Pseudobulbar affect had positive correlation with fatigue and also depression while apathy negatively correlate with pseudobulbar affect or fatigue. Additionally, apathy and depression correlated negatively. There was no relation between cognition and depression and/or disease duration and/or other scales’ scores. Conclusion: Pseudobulbar affect and apathy are quite common symptoms in MS patients, that are cross-cutting issues. Also, apathy may be an independent neuropyschiatric symptom of MS that need to be approached separately.

Keywords:

MS, apathy, pseudobulbar affect,

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