Bengü Gülhan AYDIN, Gamze KÜÇÜKOSMAN, Özcan PİŞKİN, Dilek OKYAY, Bilgehan AÇIKGÖZ, Hilal AYOĞLU

Mantar zehirlenmesinde akut karaciğer yetmezliğinin yordayıcısı olarak nötrofil-lenfosit oranının rolü

Amaç: Çalışmamızda mantar zehirlenmeleri sonucunda karaciğer yetmezliği veya transplantasyon ihtiyacını önceden tahmin edilmesinde nötrofil/lenfosit oranı (NLO) ve demografik özelliklerin birlikte değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Hastalar cinsiyet, yaş, hastaneye başvuru ayı, acil servise başvuru semptomları, vital bulgular, laboratuvar değerleri, ilk semptomlarına göre zehirlenme ciddiyet skoru (ZCS), şikayetlerinin başlama zamanı açısından değerlendirildi. Hastalar karaciğer fonksiyon testlerinin bozulup bozulmamasına göre iki gruba ayrıldı. ZCS’ye göre ve akut karaciğer yetmezliğinin olup olmamasına göre NLO değerlendirildi.Bulgular: Yaşları 16-85 arasında olmak üzere 84 hasta çalışmaya dahil edildi. NLO karaciğer fonksiyon testleri bozulmuş hastalarda (10.82±8.7), karaciğer fonksiyon testleri normal olanlara (5.66±4.71) göre istatistiksel olarak anlamlıydı. NLO’nun akut karaciğer yetmezliği gelişen hastalarda (17.77±9.44) şifa ile taburcu edilen hastalara göre (5.72±4.64) anlamlı derecede yüksek olduğu gözlendi. Cut-off değerinin 9.65 olduğu görüldü.Sonuç: Mantar zehirlenmeleri sonucunda gelişebilecek karaciğer yetmezliği veya transplantasyon ihtiyacını erken tahmin edilmesinde NLO’nun faydalı olabileceğini düşünmekteyiz.

Anahtar Kelimeler:

Akut karaciğer yetmezliği, Mantar zehirlenmesi

The role of neutrophil-lymphocyte ratio as a predictor of acute hepatic failure in mushroom poisoning

Purpose: This study aimed to evaluate the value of neutrophil/lymphocyte ratio (NLR) together with the demographic characteristics in predicting liver insufficiency or transplantation need following mushroom poisoning. Materials and Methods: The patients were evaluated in terms of various parameters including gender, age, the month of admission, symptoms on emergency service admission, vital findings, laboratory findings, poisoning severity score (PSS) according to initial symptoms, and onset time of symptoms. The patients were divided into two groups according to whether the liver function tests were deteriorated or not. NLR was assessed according to PSS in patients with and without acute liver failure.Results: A total of 84 patients, aged 16-85 years, were included in the study. Neutrophil/lymphocyte ratio was 10.82±8.7 in patients with impaired liver function tests and statistically significant compared to the patients with normal liver function tests (5.66±4.71). NLR was statistically significantly higher in patients who developed acute liver failure and in those with high poisoning severity score. The cut-off value was founded as 9.65.Conclusion: NLR may be a useful predictor of liver failure or transplantation need, which develops as a result of mushroom poisoning.

Keywords:

Acute hepatic failure Mushroom poisoning, Neutrophil lymphocyte ratio,

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