Son yıllarda kronik hastalıkların ortaya çıkmasında, kronik düşük derece inflamasyonun rolü üzerinde durulmaktadır. Kronik düşük derece inflamasyon, sistemik dolaşım ve çeşitli dokularda inflamatuvar medyatörlerin ve bazı proinflamatuvar sitokinlerin artışı ile karakterize olan metabolik bir süreçtir. C reaktif protein (CRP), tümör nekrozis faktör-α (TNF-α), interlökin-1 (IL-1), interlökin-4 (IL-4), interlökin-6 (IL-6), toll benzeri reseptör-4 (TLR-4) kronik düşük derece inflamasyonda rol oynayan bazı proinflamatuvar moleküllerdir. Güncel çalışmalarda, hazır ve işlenmiş besinlerin tüketimiyle artan fruktoz ve doymuş yağ asitleri alımının kronik düşük derece inflamasyon oluşumunda etkileri olduğu gösterilmektedir. Bu derlemede, diyetle yüksek fruktoz ve doymuş yağ asitleri alımının, proinflamatuvar medyatörler aracılığıyla kronik düşük derece inflamasyon oluşumuna etkisi incelenmiştir.
In recent years, the role of chronic low grade inflammation in the emergence of chronic diseases has been emphasized. Chronic low grade inflammation is a metabolic process characterized by systemic circulation and increased inflammatory mediators and some proinflammatory cytokines in various tissues. C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-4 (IL-4), interleukin-6 (IL-6), toll like receptor-4 (TLR-4) are some proinflammatory molecules that play a role in the chronic low grade inflammation. Recent studies have shown that fructose and saturated fatty acids, which are consumed with increased consumption of processed foods in the current diet, might trigger chronic low grade inflammation. In this review, the effects of dietary high fructose and saturated fatty acids on development of chronic low grade inflammation through some proinflammatory mediators were examined.
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