İntrauterin gelişme geriliğinde maternal serum Elabela düzeyleri

Amaç: Bu çalışmanın amacı, Elabela'nın intrauterin büyüme geriliğinin (IUGR) etyopatogenezindeki rolünü araştırmaktı. Gereç ve Yöntem: Bu prospektif çalışmaya 43 sağlıklı gebe ve 46 IUGR'li gebe dahil edildi. Kontrol grubundan ve IUGR grubundan doğum sırasında anneden kan alındı. Elabela seviyeleri anne serumunda ELISA yöntemi ile analiz edildi. Bulgular: Kontrollere kıyasla IUGR hastalarında daha düşük Elabela seviyeleri (IUGR: 1.09 (0.61-15.61) ng/mL ve Kontrol: 1.44 (0.37-31.33) ng/mL) gözlendi. Elabela seviyeleri, gebelik haftası ve yenidoğan ağırlığı ile pozitif korelasyon gösterdi. (sırasıyla r = 0.263, p = 0.013 ve r = 0.259; p = 0.014). Sonuç: Bu çalışma, anne serumunda Elabela'daki azalmanın IUGR etyopatogenezindeki rolünü ortaya koyan ilk çalışma olma özelliğini taşımaktadır. Bu, Elabela'nın IUGR'li vakalarda potansiyel bir ilaç hedefi olabileceğini düşündürmektedir.

Anahtar Kelimeler:

İntranuterin Gelişme Geriliği, Elabela, Gebelik

Maternal plasma Elabela levels in intrauterine growth restriction

Purpose: The aim of this study was to investigate the role of Elabela in the etiopathogenesis of intrauterine growth retardation (IUGR). Materials and Methods: The present prospective study included 43 healthy pregnant women and 46 pregnant women with IUGR. Maternal serum were collected from the control group and IUGR group at time of delivery. Elabela levels were analyzed in maternal serum through ELISA method. Results: Lower Elabela levels (IUGR: 1.09 (0.61-15.61) ng / mL and Control: 1.44 (0.37-31.33) ng / mL) were observed in IUGR patients compared to controls. Elabela levels were positively correlated with gestational week and neonatal weight. (r = 0.263, p = 0.013 and r = 0.259, respectively; p = 0.014). Conclusion: The present study serves as the first study revealing the role of the decrease in Elabela in maternal serum on the etiopathogenesis of IUGR. This suggests that Elabela could be a potential drug target in cases with IUGR.

Keywords:

intrauterine growth restriction, Elabela, Pregnancy,

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