Senem ERTUĞRUL MUT, İpek SÖNMEZ, Ali BOZKURT

Dirençli migren tedavisi sonrası gelişen propofol bağımlılığı

Propofol hızlı sedatif etki gösteren oldukça potent intravenöz uygulanan anestetik bir ajandır. Son zamanlarda refrakter başağrılarında bir tedavi seçeneği olarak kullanılmaya başlanmıştır. Bu vakada 38 yaşında bayan hastada refrakter başağrıları nedeniyle propofol tedavisi uyganmış ve propofole karşı bağımlılık gelişmiştir. Propofol tedavisinin kesilmesi ile hastada çok şiddetli çekilme belirtileri gözlenmiş ve tedavi başlanmıştır.Son yıllarda propofolün bağımlılık yapıcı etkisi, kötüye kullanım potansiyeli ve sonuç olarak intihar girişimi olan vakalarla sık karşılaşılmaktadır. Refrakter başağrılarında intravenöz propofol tedavisi oldukça etkili olmakla beraber bağımlılık yapıcı etkisi ve kötüye kullanımı mutlaka göz önünde bulundurulmalıdır.

Propofol addiction after treatment of refractory migraine

Propofol is a potent intravenous anesthetic agent that rapidly induces sedation. Recently it has been considered as a treatment option for refractory headaches.We report a case of 38 years of female who has received propofol treatment for her refractory headaches and severe dependence on propofol has occured. She had excessive withdrawal symptoms after discontinuing propofol and was succesfully treated. The abuse and dependency potential of propofol has recently been recognized and several cases of suicide have emerged. Although intravenous propofol is an efficacious treatment for patients with refractory headaches, the severe dependency and abuse potential must be taken into consideration.

Keywords:

intractable headache, propofol, drug abuse,

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