D vitamini eksikliğinin yaşlı hastalarda osteoartrit ve kemik mineral dansitesi üzerine etkisi.

Amaç: Farklı kemik mineral yoğunluğu (KMY) olan kadın ve erkek erken ve geç evre osteoartritli (OA) yaşlılarda, vitamin D düzeyinin OA ve KMY üzerine etkisini ve ayrıca D vitamini ve diz fonksiyon skorları arasındaki ilişkiyi belirlemeyi amaçladık.Gereç ve Yöntem: Çalışmaya diz OA olan yüz kırk iki kadın ve yüz otuz beş erkek hasta alındı. Diz OA erken ve geç evre olarak sınıflandırıldı. Western Ontario ve McMaster Universities Osteoarthritis indexi (WOMAC) indeksi, Knee Injury ve Osteoarthritis Outcome Skoru (KOOS) hesaplandı ayrıca KMY ve D vitamini düzeyleri ölçüldü. Bulgular: Kadın OA de D vitamini düzeyleri erkek OA grubuna göre istatistiksel olarak anlamlı derecede düşüktü. Kadın OA hastalarında kalsiyum ve fosfor düzeyleri erkek OA grubuna göre anlamlı olarak daha yüksekti. Osteoporoz, osteopeni ve normal KMY olan erken ve geç dönem OA hastalarında vitamin D, vitamin B12, kalsiyum, fosfor, WOMAC indeksi ve KOOS skorları arasında fark yoktu. Osteoporozlu erken evre ve geç evre OA olan erkek hastalarda osteopenisi ve normal KMY olanlara göre WOMAC indexi anlamlı olarak daha yüksekti. Kadın OA olan hastalarda yaş odds oranı (OR) 1,047 (% 95 CI = 1,009-1,086), erkek OA olan hastalarda OR = 1.090 (% 95 CI = 1,021-1,163) idi.Sonuç: D vitamini takviyesinin, osteoporozun ilerlemesini yavaşlattığı, ağrıyı azalttığı, KMY arttırdığı söylenebilir, ancak OA progresyonu ve diz fonksiyon skorları üzerinde hiçbir etkisi yoktur.

Anahtar Kelimeler:

Vitamin D eksikliği, Osteoartrit, Kemik Mineral Yoğunluğu, WOMAC indeksi, KOOS skoru

Effect of vitamin D deficiency on osteoarthritis and bone mineral density in elderly patients

Purpose: We aimed to determine the effect of inadequate vitamin D level on osteoartritis (OA) and bone mineral density (BMD) in female and male elderly patients with early and late stage OA with different BMD, and also the relationship between vitamin D and knee function scores in female and male OA patients.Materials and Methods: One hundred and fortytwo female and one hundred thirty-five male knee OA patients were enrolled in the study. The knee OA was classified as early and late stage. WOMAC score, KOOS score, BMD and Vitamin D levels were measured. Results: Vitamin D levels patients were statistically significantly lower in female OA than male OA group. Calcium and phosphorus levels were significantly higher in female OA patients than male OA group. There was no difference between vitamin D, vitamin B12, calcium, phosphorus, WOMAC score and KOOS scores in early and late stage OA patients with osteoporosis, osteopenia and normal BMD. WOMAC score was significantly higher in male patients with osteoporosis early stage and late stage OA than patients with osteopenia and normal BMD. The age odds ratio (OR) was 1,047 (95% CI = 1,009-1,086) in female OA patients, and OR was 1.090 (95% CI = 1,021-1,163) in male OA patients.Conclusion: Vitamin D supplementation may be said increase BMD, slow down the progression of osteoporosis, reduce pain, but have no effect on OA progression and knee function scores.

Keywords:

Vitamine D deficiency, Osteoartritis, Bone Mineral Density, WOMAC score, KOOS score,

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