Erdal Tunç, Osman DEMİRHAN, Ayfer Pazarbaşı, Deniz Taştemir, Ali İrfan Güzel, Mülkiye KASAP, Fatma Tuncay ÖZGÜNEN, Bertan Yılmaz, Sabriye KOCATÜRK-SEL

Çukurova Populasyonunda Gebelik Zamanı ve Maternal Yaşın Fetal Cinsiyet Oranı Üzerine Olan Etkisi

Amaç: Bu çalışmanın amacı, çukurova ve çevresindeki populasyonda konsepsiyon ayı, ebeveynlerin yaşları, mevsimsel değişimler, ebeveynlerin alkol ve sigara kullanım durumları gibi çevresel değişkenlerin fetal cinsiyet oranını etkileyip etkilemediklerini tespit etmektir. Materyal ve Metod: Bu çalışmada, 2005-2007 yılları arasında amniyosentez maksadıyla prenatal tanı laboratuvarımıza yönlendirilen hastaların verilerini analiz ettik. Istatistiksel analiz için ki-kare, Fisher"s exact ve T testlerini uyguladık. Bulgular: Konsepsiyon zamanı ile primer cinsiyet oranı arasında bir ilişki tespit edilemedi. Aylara göre primer cinsiyet oranındaki değişimlerin istatistiksel olarak anlamlı olmadığı gözlendi. İstisna olarak eylül ayındaki değişim kaydedildi. Eylül ayında istatistiksel olarak anlamlı bir şekilde cinsiyet oranının erkeğe doğru değiştiği saptandı (erkek:kadın oranı=1.8). Sonuç: Yaz/sonbahar fotoperiyodunda bulunan eylül ayındaki iklimsel değişimin, cinsiyet oranındaki bu farklılaşmayı etkilediğini düşünmekteyiz.

Anahtar Kelimeler:

Karyotipleme, konsepsiyon ayı, primer cinsiyet oranı, prenatal tanı, istatistiksel analiz

Effect of conception time and maternal age upon fetal sex ratio in Çukurova population, Adana-Turkey

Purpose: This investigation was conducted to determine whether the month of conception, parental age, and environmental factors such as seasonal variation, consumption of alcohol and cigarette by parents, play a role on sex ratio at pregnancy in Çukurova region and surrounding area population (Turkey). Materials and Methods: We have analyzed tha data of patients who were referred to our prenatal diagnosis laboratory for amniosynthesis with the purpose of karyotyping between the years of 2005-2007. We used Pearsen Chi-square, Fisher"s exact and T-tests for statistical analyses. Result(s): No association was established between the primary sex ratio and time for pregnancy. Differences in primary sex ratio among the months were not statistically significant, but the difference for the month of September was noted. For september, we have found statistically significant distortion of sex ratio toward male, (males:females ratio=1.8). Conclusion: In conclusion, our speculation is that the climate change in September may affect the primary sex ratio under the summer/autumn photoperiod.

Keywords:

Karyotyping, month of conception, primary sex ratio, prenatal diagnosis, statistical analyses,

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Yazışma Adresi / Address for Correspondence: Dr. Erdal Tunç Çukurova University Faculty of Medicine, Department of Medical Biology and Genetics 01330 Balcalı-ADANA Tel. 90 322 3386060-3498 Fax. 90 322 3386572 e-mail: terdal@cu.edu.tr geliş tarihi/received :29.07.2013 kabul tarihi/accepted:16.09.2013