Nebile DAĞLIOĞLU, Pınar EFEOĞLU, Mete K. GÜLMEN, Necmi ÇEKİN

Akut Endosülfan Zehirlenmesinde Postmortem Organ Dağılımı : Olgu Sunumu

Çalışmamızda, kaza sonucu endosülfanla zehirlenen iki ölüm olgusunda endosülfanın vücutta postmortem dağılımının gösterilmesi amaçlanmıştır. Olgulardan alınan kan, karaciğer, böbrek, beyin ve mide içerikleri Gaz Kromatografi-Kütle Spektrometresinde (GC/MS) çalışıldı. Biyolojik örneklerde endosülfan izomer (α-Endosülfan ve β-Endosülfan) ve metabolitlerin (endosülfan sülfat ve endosülfan eter) düzeyleri araştırıldı. Birinci olgunun kanında α-endosülfan 0.47 mg/l, β-endosülfan 0.05 mg/l, ikinci olguda α-endosülfan kanında 0.24 mg/l, β-endosülfan ise 0.03 mg/l olarak bulundu. Endosülfan düzeyinin en yüksek olduğu örneğin mide içeriği olduğu saptandı. Birinci olguda mide içeriğinde α-endosülfan 2.4 mg/kg ve β-endosülfan 1.1 mg/kg, ikinci olguda α-endosülfan 3.4 mg/kg ve β-endosülfan 2.65 mg/kg olarak bulundu. Her iki olgunun karaciğer, beyin ve böbreklerdeki α-endosülfan, β-endosülfan, endosülfan eter ve endosülfan sülfat miktarları da hesaplandı.

Anahtar Kelimeler:

Endosülfan; Postmortem doku; GS/MS.

Distribution of Postmortem Tissue in Acute Endosulfan Poisoining: Case Report

In this study, we aimed to determine the distribution of endosulfan in the two postmortem cases, who died due to accidental poisoning. The blood, liver, kidney, brain and stomach content samples obtained from cases were studied with Gas Chromatography-Mass Spectrometry (GC/MS). In the biologic samples, endosulfan isomer (α-Endosulfan and β- Endosulfan) and metabolites (endosulfan sulfate and endosulfan ether) levels were examined. The endosulfan concentrations in the blood were determined as: α- endosulfan was 0.47 mg/l and β-endosulfan was 0.05 mg/l in the first case; α-endofulsan was 0.24 mg/l and β-endosulfan was 0.03 mg/l in the second case. The highest levels of endosulfan were found in the stomach contents. The endosulfan concentrations in the stomach contents were determined as: α-endofulsan was 2.4 mg/kg and β-endosulfan was 1.1 mg/kg in the first case, α- endosulfan was 3.4 mg/kg and β-endosulfan was 2.65 mg/kg in the second case. The liver, brain and the kidney; α- endosulfan, β-endosulfan, endosulfan sulfate and endosulfan ether levels of both cases were examined in our studies as well.

Keywords:

Endosulfan; Postmortem tissue; GC/MS.,

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Yazışma Adresi / Address for Correspondence: Dr. Nebile Dağlıoğlu Çukurova Üniversitesi Tıp Fakültesi, Adli Tıp Anabilim Dalı 01330 Balcalı-ADANA e-mail: nebiled@hotmail.com geliş tarihi/received :21.12.2012 kabul tarihi/accepted:03.01.2013