Üçüncü Basamak Bir Pediatrik Endokrinoloji Merkezinde İzlenen Ağır Boy Kısalığı Vakalarının Etiyolojik Değerlendirmesi

Objective: The aim of this study was to describe the characteristics and the etiological profile of children with severe short stature evaluated at a tertiary Pediatric Endocrinology centre in Istanbul. Method: Randomly selected 500 patients with the diagnosis of severe short stature height SDS

Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre

Amaç: Araştırmamızın amacı İstanbul’da üçüncü basamak bir Pediatrik Endokrinoloji merkezinde izlenen ağır boy kısalığı olgularının etiyolojik profilini ve karakteristiklerini incelemektir. Yöntem: Rastgele seçilen 500 ağır boy kısalığı boy SDS

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  • 1. Sen Y, Bozdag S. The etiological distribution of patients admitted to the pediatric endocrinology clinic. Fırat University Journals of Health Sciences 2008;22(2): 53-8.
  • 2. Rosenfield R, Cuttler L. Short stature. In: DeGroot LJ, Jamesan JL, eds. Endocrinology. 4th ed. Philadelphia: WB Saunders, 2001:485-94.
  • 3. Marcovitch H. Failure to thrive. Br Med J. 1994;308: 35-8. https://doi.org/10.1136/bmj.308.6920.35
  • 4. Frindik JP, Kemp SF, Hunold JJ. Near adult heights after growth hormone treatment in patients with idiopathic short stature or idiopathic growth hormone deficiency. J Pediatr Endocrinol Metab 2003;16:607-12.
  • 5. Vogiatazi MG, Copland KC. The short child. Pediatr Rev 1998;19:92-9.
  • 6. Thomas Aceto JR, Dempsher D. Short stature and slow growth in the young. In: Becker KL, eds. Principles and Practice of Endocrinology and Metabolism. 3rd ed. Philadelphia: Lippincott Williams and Wilkins, 2001:1784-97.
  • 7. Rosenfeld RG. Growth retardation. In: Sperling MA, eds. Pediatric Endocrinology. Philadelphia: WB Saunders, 1996:135-57.
  • 8. Reiter O, Rosenfeld Ron G. Growth retardation. In: Williams RH, Wilson JD, eds. Williams Textbook of Endocrinology. 9th ed. Philadelphia: WB Saunders, 1998:1453-8.
  • 9. Jan M Wit. International Classification of Pediatric Endocrine Diagnoses. Horm Res Paediatr. 2016;86(3): 212-4. https://doi.org/10.1159/000448893
  • 10. American Academy of Pediatrics. Recommendations for Preventive Pediatric Health Care Committee on Practice and Ambulatory Medicine. Pediatrics 2000;105:645-6. https://doi.org/10.1542/peds.105.3.645
  • 11. Lacey KA, Parkin JM. Causes of short stature. A community study of children in Newcastle upon Tyne. Lancet 1974;1(7846):42-5. https://doi.org/10.1016/S0140-6736(74)93041-4
  • 12. Voss LD. Growth hormone therapy for the short normal child: who needs it and who wants it? The case against growth hormone therapy. J. Pediatr. 2000;136:103-6. https://doi.org/10.1016/S0022-3476(00)90058-1
  • 13. Voss LD, Mulligan J, Betts PR, Wilkin TJ. Poor growth in school entrants as an index of organic disease: the Wessex growth study. BMJ 1992;305:1400-2. https://doi.org/10.1136/bmj.305.6866.1400
  • 14. Zafer Y, Kandemir N, Yordam N. Etiological distribution of short stature: Evaluation of 1013 cases. Journal of Child Health and Diseases 1999;42:205-13.
  • 15. Demirel F, Bideci B, Camurdan MO, Arga M, Cinaz P. Etiological causes of short stature in children. Turkish Archives of Pediatrics 2005;40(1):39-43.
  • 16. Fenton TR, Kim JH. A systematic review and metaanalysis to revise the Fenton growth chart for preterm infants. BMC Pediatr. 2013;13:59. https://doi.org/10.1186/1471-2431-13-59
  • 17. Neyzi O, Bundak R, Darendeliler F, Günöz H. Büyüme Gelişme ve Bozuklukları. In: Neyzi O, Ertuğrul T, eds. Pediyatri Cilt 1, 4th ed, Istanbul: Nobel Tıp Kitapevleri, 2010:89-149.
  • 18. Marshall WA, Tanner JM. Variations in pattern of pubrtal changes in girls. Arch Dis Child. 1969;44:291-303. https://doi.org/10.1136/adc.44.235.291
  • 19. Marshall WA, Tanner JM. Variations in pattern of pubrtal changes in boys. Arch Dis Child. 1970;45:13-23.
  • 20. Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, Neyzi O. Body mass index for Turkish children aged 6 to 18 years. Acta Paediatr 2006;95:194-8. https://doi.org/10.1080/08035250500334738
  • 21. Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr. 2006;95:1635-41. https://doi.org/10.1080/08035250600652013
  • 22. Neyzi O, Gunoz H, Furman A, Türk çocuklarında vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri. Çocuk Sağlığı ve Hastalıkları Dergisi 2008;51:1-14.
  • 23. WHO Multicentre Growth Reference Study Group. WHO Child Growth Standards Acta Paediatrica Supplement 2006;450.
  • 24. De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bulletin of the World Health Organization, 2007;85(9):649-732. https://doi.org/10.2471/BLT.07.043497
  • 25. McLaren DS, Read WWC. Classification of nutritional status in early childhood. Lancet 1972;2(7769):146-8. https://doi.org/10.1016/S0140-6736(72)91324-4
  • 26. Tanner JM, Goldstein H, Whitwhouse RH. Standards for children’s height at age 2-9 years allowing for height of parents. Arch Dis Child. 1970;45:755-62. https://doi.org/10.1136/adc.45.244.755
  • 27. Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the GreulichPyle hand standart. J Pediatr. 1952;40:423-41. https://doi.org/10.1016/S0022-3476(52)80205-7
  • 28. Şükür M, Baş F, Darendeliler F ve ark. Pediatrik endokrinoloji polikliniğine müracaat eden hastaların etiyolojik dağılımı: pilot çalışma. Pediatrik Endokrinoloji Kongresi Bildiri Özet Kitabı, 14-17 Eylül 2006, Konya, 2006:140.
  • 29. Lindsay R, Feldkamp M, Harris D, Robertson J, Rallison M. Utah Growth Study: growth standards and the prevalence of growth hormone deficiency. J Pediatr. 1994;125:29-35. https://doi.org/10.1016/S0022-3476(94)70117-2
  • 30. Song KC, Jin SL, Kwon AR, Chae HW, Ahn JM, Kim DH, et al. Etiologies and characteristics of children with chief complaint of short stature. Ann Pediatr Endocrinol Metab. 2015;20:34-9. https://doi.org/10.6065/apem.2015.20.1.34
  • 31. Strufaldi MWL, da Silva EMK, Puccini RF. Follow-up of children and adolescents with short stature: the importance of the growth rate. Sao Paulo Med J. 2005;123(3):128-33. https://doi.org/10.1590/S1516-31802005000300008
  • 32. Shiva S, Nikzad A. Etiology of short stature in East Azerbaijan, Iran. Iran J Pediatr. 2009;19:35-40.
  • 33. Moayeri H, Aghighi Y. A prospective study of etiology of short stature in 426 short children and adolescents. Arch Iranian Med. 2004;7:23-7.
  • 34. Lashari SK, Korejo HB, Memon YM. To determine frequency of etiological factors in short statured patients presenting at an endocrine clinic of a tertiary care hospital. Pak J Med Sci. 2014;30:858-61. https://doi.org/10.12669/pjms.304.4619
  • 35. Zargar AH, Laway BA, Masoodi SR. An aetiological profile of short stature in the Indian subcontinent. J Pediatr Child Health. 1998;34:571-6. https://doi.org/10.1046/j.1440-1754.1998.00308.x
  • 36. Papadimitriou A, Douros K, Papadimitriou DT, Kleanthous K, Karapanou O, Fretzayas A. Characteristics of the short children referred to an academic paediatric endocrine clinic in Greece. J Paediatr Child Health. 2012;48:263-7. https://doi.org/10.1111/j.1440-1754.2011.02256.x
  • 37. Bhadada SK, Bhansali A, Ravikumar P, Kochhar R, Nain CK, Dutta P, et al. Changing scenario in aetiological profile of short stature in India-growing importance of celiac disease: a study from tertiary care centre. Indian J Pediatr. 2011;78(1):41-4. https://doi.org/10.1007/s12098-010-0227-6
  • 38. Tunçbilek E, Özgüç M. Application of medical genetics in Turkey. The Turkish Journal of Pediatrics 2007;49: 353-9.
  • 39. Binder G. Short stature due to SHOX deficiency: Genotype, phenotype, and therapy. Horm Res Paediatr. 2011;75:81-89. https://doi.org/10.1159/000324105
  • 40. Saenger P, Czernichow P, Hughes I, Reiter EO. Small for gestational age: Short stature and beyond. Endocr Rev. 2007;28(2):219-51. https://doi.org/10.1210/er.2006-0039
  • 41. Chernausek SD. Mendelian genetic causes of the short child born small for gestational age. J Endocrinol Invest. 2006;29(1):16-20.
  • 42. Jee YH. Genetics of Short Stature. Endocrinol Metab Clin North Am. 2017;46(2):259-81. https://doi.org/10.1016/j.ecl.2017.01.001