Serap ÖZMEN, Neşe YARALI, Elif ÇALIŞKAN ÖZTÜRK, Bahattin TUNÇ

Kemoterapinin Tetiklediği Akral Eritem: Vaka Sunumu

Kemoterapinin tetiklediği akral eritem, 5-flurouracil, doxo- rubicin ve cytosin arabinosid gibi kemoterapötiklerin neden olduğu lokalize, toksik bir reaksiyondur. Çocukluk yaş gru- bunda ender olarak görülür. B cell ALL tanısı alan vakamız- da, St. Jude Total XIII konsolidasyon tedavisinden üç gün sonra yüz, boyun, göğüs ön duvarında makulopapüler döküntü gelişti. Bir gün sonra hastanın her iki el ayası ve ayak tabanında yaklaşık üç cm çapında çevresi hiperemik, iyi sınırlı, ağrılı, büllöz lezyonlar gelişti. Bu bulgularla has- tada yüksek doz metotreksata bağlı akral eritem ve bülloz reaksiyon düşünüldü. Sonuç olarak, kemoterapötiklere bağlı gelişen akral eritemde, kemoterapi uygulamaları öncesi ve/ veya sırasında sistemik kortikosteroid verilebilir

Anahtar Kelimeler:

Akral eritem, akut lenfoblastik lösemi, büllöz varyant, çocukluk çağı, ilaç reaksiyonu

Chemotherapy Induced Acral Erythema: A Case Report

Chemotherapy induced acral erythema is localized response to some chemotherapeuticals such as 5-fluorouracil, doxo- rubicin, and cytosin arabinosid. It is rarely seen in childho- od. Our patient was diagnosed with B precursor acute lymphoblastic leukemia. Three days after St. Jude Total XIII consolidation therapy, itchy, maculopapular rashes appea- red on her face, neck, and upper trunk. One day later, well- demarcated erythema and several painful, 1-2 cm diameter bullous lesions were seen on her palms and soles, possibily due to methotrexate induced acral erythema and bullous reaction. In conclusion, chemotherapy induced acral erythe- ma might be prevented by corticostreoid use simultaneously or before methotrexate therapy

Keywords:

Acral erythema, acute lymphoblastic leukemia, bullous variant, childhood, drug reactions,

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