Yasin ŞAHİN, Derya AYDIN

Hepatit A virus infeksiyonu ile bağlantılı nefrotik sendrom

Hepatit A tüm dünyada sıkça görülen, hemen her zaman fekal-oral yolla bulaşan bir infeksiyondur. Genellikle gürültülü bir klinik tablo ile başlayarak, hafif bir gidiş gösterir. Hepatit A virus infeksiyonuna bağlı hafif proteinüri ve mikroskopik hematüri görülebilmektedir. Nefrotik sendrom ender olarak bildirilmektedir. Bu makalede hepatit A infeksiyonuna bağlı nefrotik sendrom geliştiği düşünülen sekiz yaşındaki bir kız vaka sunuldu. Hepatit A virus infeksiyonu nefrotik sendroma neden olabilmektedir. Bu nedenle, nefrotik sendromlu vakalarda ayırıcı tanıda düşünülmelidir.

Anahtar Kelimeler:

Nefrotik sendrom, Hepatit A virüs, Hepatit A, Çocuk

Nephrotic syndrome associated with hepatitis A virus

Hepatitis A is a common worldwide seen infection which is transmitted by fecal-oral route. It usually begins with acute symptoms, but continues insidiously. Mild proteinuria and microscopic hematuria can be seen as a result of hepatitis A infection. Nephrotic syndrome is rarely reported. An 8 year-old girl who has developed nephrotic syndrome due to hepatitis A infection is presented. Hepatitis A virus infection may cause nephrotic syndrome, thus it must be the in considered differential diagnosis of patients with nephrotic syndrome.

Keywords:

Nephrotic Syndrome, Hepatitis A virus, Hepatitis A, Child,

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1.Garel D, Vasmant D, Mougenot B, Bensman A. Glomerular nephropathy with mesengial proliferation and acute hepatitis A virus infection: 2 cases. Ann Pediatr 1986; 33:185-8.
2.Demircin G, Oner A, Tinaztepe K, Bulbul M, Demiriz M, Erdoğan O. Acute glomerulonephritis in hepatitis A virus infection. J Pediatr Gastroenterol Nutr 1998; 27:86-9.
3.Zikos D, Grewal KS, Craig K, Cheng JC, Peterson DR, Fisher KA. Nephrotic syndrome and acute renal failure associated with hepatitis A virus infection. Am J Gastroenterol 1995; 90:295-8.
4.Kramer MR, Herskho C, Slotki IN. Acute renal failure associated with non-fulminant type A viral hepatitis. Clin Nep-hrol 1986; 25: 219.
5.Eng C, Chopra S. Acute renal failure in non-fulminant hepatitis A. J Clin Gastroenterol 1990; 12:717-8.
6.Geltner D, Naot Y, Zimhoni O, Gorbach S, Bar-Khayim Y. Acute oliguric renal failure complicating type A non-fulminant viral hepatitis. A case presentation and review of literature. J Clin Gastroenterol 1992; 14:160-2.
7.Chio JR, Bakir AA. Acute renal failure in hepatitis A. Int J Artif Organs 1992; 15:413-6.
8.Mathur RC, Mathur NC. Mesangial proliferative glomerulonephritis and nephrotic syndrome with hepatitis A virus infection. Indian Pediatr 1996; 33:1051-3.
9.Aydin A, Mikla S, Ficicioglu C, Ozdemir S, Ada] E. Nephrotic syndrome associated with hepatitis A virus infection. Pediatr Infect Dis J 1999; 18:391.
10.Lai KN, Lai FM. Clinical features and the natural course of hepatitis B virus related glomerulopathy in adults. Kidney Int 1991; 35:40-5.
11.Johnson RJ, Gretch DR, Yamabe H, et al. Membranoproli-ferative glomerulonephritis associated with hepatitis C virus infection. N Engl J Med 1993; 328:465-70.
12.Stehman-Breen C, Willson R, Alpers CE, Gretch D, Johnson RJ. Hepatitis C virus associated glomerulonephritis. Curr Opin Nephrol Hypertens 1995; 4:287-94.
13.Uchiyama-Tanaka Y, Mori Y, Kishimoto N, et al. Membranous glomerulonephritis associated with hepatitis C virus infection: case report and literature review. Clin Nephrol 2004; 61:144-50.
14.Mathiesen LR, Drucker J, Lorenz D, Wagner JA, Gerety RJ, Purcell RH. Localisation of hepatitis A antigen in marmoset organs doring infection with hepatitis A virus. J Infect Dis 1987; 138:369-77.