Poliaminler ve kanser; Kanserli hastaların beslenmesinde poliaminlerin rolleri

Poliaminler (putresin, spermidin ve spermin) tüm canlılarda bulunan bazik moleküllerdir. Hücre büyümesi, farklılaşması, DNA, RNA ve protein sentezinden sorumludurlar. Hücrelerde endojen olarak üretildikleri gibi diyet yoluyla ekzojen olarak da alınırlar. Kanserli dokularda, poliamin sentezinden sorumlu enzimlerin aktiviteleri artar, buna bağlı olarak poliamin sentezinde de artış görülür. Dolayısıyla kanser hastalarının kan ve idrarında poliamin seviyesi yüksektir. Düşük poliamin içerikli diyetlerin kanser hastalarının yaşam kalite ve sürelerini olumlu etkilediği belirtilmektedir. Bu derlemenin amacı, poliaminlerin kanser oluşumundaki rolleri ve düşük poliamin içeren diyetle beslenmenin, hastalığın gelişimi ve kanserli hastaların yaşam kaliteleri üzerine etkilerini anlatmak, şimdiye kadar yapılan çalışmaları özetlemektir.

Anahtar Kelimeler:

Poliamin, kanser, beslenme, putresin, spermidin, spermin

Polyamines and cancer; The role of diet polyamines in patients with cancer

Polyamines (putrescine, spermidine and spermine) are basic compounds that are found in all living systems. They are responsible for cell proliferation and differentiation, DNA, RNA and protein synthesis. In addition to the endogenous synthesis of polyamines inside the cell, exogenous intake is also possible. The activity of enzymes that are involved in polyamine synthesis increases in cancer tissues, and consequently the level of polyamines rise. Therefore, polyamine concentrations in serum and urine of cancer patients are found in high levels. Reducing polyamine dietary intake has been shown to be beneficial on the quality of life in cancer patients. The aim of this review is to explain the functions of polyamines in cancer and the importance of low dietary intake of polyamines on cancer development and the treatment of patients and to summarize the literature.

Keywords:

Polyamine, cancer, nutrition, putrescine, spermidine, spermine,

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