Kafein 1,3,7-trimetilksantin kimyasal yapısında, biyoaktif bir bileşendir.

Caffeine is a psychoactive component with a chemical composition of1,3,7-trimethylxanthine. Coffee, tea, energy drink, and chocolate are themain sources of caffeine. There are several positive health effects of caffeineon diabetes, Parkinson’s disease, and cardiovascular disease. However, therelationship between caffeine consumption and reproductive health iscontroversial. The aim of the present study was to determine the effects ofcaffeine consumption on fertility. A literature search was conducted usingthe electronic databases PubMed, Web of Science, Cochrane, and LILACSwith the search terms “fertility,” “infertility,” “fecundability,” “reproductive,”“caffeine,” “coffee,” “tea,” and “caffeinated.” An additional manual search wasalso performed for missing articles. At the end of the search, a total of 13studies were included in the present study. Six studies reported negativeand two studies reported positive effects of caffeine on fertility by severalmechanisms such as affecting sex hormones and reducing clearanceduring the luteal phase. However, no association was found between caffeineand fertility or fecundability in five studies. According to study resultsthat revealed negative effects of caffeine, it may be recommended to malesand females who are planning to conceive to decrease caffeine intake, especiallyfrom coffee. It may also be recommended to consume other typesof healthy beverages and foods without caffeine