Eda KAYA, Alican KARAKOÇ, Mehmet VELİDEDEOĞLU, Salih PEKMEZCİ, Sinan TRABULUS, Nurhan SEYAHİ

Tedavinin Sirolimus’tan Everolimus’a değiştirilmesi sonucu Everolimus’a bağlı pnömonit gelişen bir böbrek transplantasyonu hastası olgusu

DOI: 10.26650/cjm.2019.43.33 Pnömonit mammalian target of rapamycin inhibitörleri tedavisinde görülen bir yan etkidir. Biz bu olguda tedavinin sirolimustan everolimusa değiştirilmesi sonucu everolimusa bağlı pnömonit gelişen bir hastayı sunuyoruz. 33 yaşında kadın hasta tedavisinin sirolimustan everolimusa değiştirilmesinden sonra gelişen kliniğimize halsizlik, öksürük, gece terlemesi ve yüksek ateş şikayetleriyle başvurdu. Toraks BT’de buzlu cam görüntüsü ve asiner nodüller görüldü. Everolimus tedavisi kesildikten sonra hastanın şikayetleri tamamen geriledi. Sirolimustan everolimusa geçiş sonucu pnömonit daha önce gözlemlenmemiştir. Everolimus alan hastalarda pulmoner semptomlar gelişirse everolimusa bağlı pnömonit düşünülmelidir.Cite this article as: Kaya E, Karakoç A, Velidedeoğlu M, Pekmezci S, Trabulus S, Seyahi N. A Case of Everolimus Related Pneumonitis Occurred After Switching Treatment from Sirolimus in a Kidney Transplant Patient. Cerrahpasa Med J 2019; 43(1): 37-39.

Anahtar Kelimeler:

Everolimus, Sirolimus, m-TOR inhibitörleri, ilaca bağlı pnömonit, böbrek transplantasyonu

A Case of Everolimus Related Pneumonitis Occurred After Switching Treatment from Sirolimus in a Kidney Transplant Patient

DOI: 10.26650/cjm.2019.43.33 Pneumonitis is a reported side effect of treatment with mammalian target of rapamycin inhibitors. In this report, we present a case of everolimus-related pneumonitis that occurred after treatment switching from sirolimus to everolimus. A 33-year-old female was admitted to our clinic with fatigue, cough, night sweats, and high fever after treatment switching from sirolimus to everolimus. Thorax CT revealed ground-glass densities and acinar nodules. After withdrawal of everolimus, complete remission was observed. Pneumonitis after treatment switching from sirolimus to everolimus has not been observed before. In patients with pulmonary symptoms during everolimus treatment, drug-related pneumonitis should be considered. Cite this article as: Kaya E, Karakoç A, Velidedeoğlu M, Pekmezci S, Trabulus S, Seyahi N. A Case of Everolimus Related Pneumonitis Occurred After Switching Treatment from Sirolimus in a Kidney Transplant Patient. Cerrahpasa Med J 2019; 43(1): 37-39.

Keywords:

Everolimus, sirolimus, mTOR inhibitors, drug-related pneumonitis, kidney transplantation,

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