Doku mühendisliği ve hücre kültürü kaynaklı yeni tedavi seçenekleri

Doku mühendisliği/onarıcı tıp; tıp, biyoloji ve mühendisliği kapsayan multidisipliner bir alandır. Bu bilimsel devrim, doku ve organların yapısı ve fonksiyonlarının canlı hücrelerin kullanımı ile onarımını amaç edinmiştir. Hücre temelli terapilerle insan sağlığı ve yaşam kalitesinin düzeltilmesi için çalışılmaktadır. Ayrıca onarıcı tıp özellikle ilaç endüstrisindeki diagnostik uygulamaları da içermektedir. Bu yazıda, doku mühendisliği ve hücre-temelli tedaviler vurgulanmış ve dünya literatürü ışığı altında bu bilimsel gelişme tartışılmaktadır.

Tissue engineering and new treatment options originated from cell-culture

Tissue engineering/regenerative medicine is multydisciplinary area including medicine, biology, and engineering. This scientific revolution aims restoration of tissue and organ structure or function with use of living cells. Human health and quality of the life are tried to improve by cell-based therapies. Apart from these, regenerative medicine has diagnostic applications especially involving drug industry. In this review, we focused on tissue engineering and cell-based therapies, and discussed this scientific progress in the light of world literature.

___

  • 1. Langer R, Vacanti JP. Tissue Engineering. Science 1993; 260: 920-926.
  • 2. Kanemaru S. Regenerative medicine in the fields of otolaryngology; head and necc region. Nippon Jibiinkoka Gakkai Kaiho 2006; 109: 1-7.
  • 3. http://txtell.lib.utexas.edu/stories/media/t0003-2.html. 4. Rice MA, Dodson BT, Arthur JA, Anseth KS. Cell-Based therapies and tissue engineering. Otolaryngol Clin North Am 2005; 38: 199-214.
  • 5. Kojima K, Bonassar LJ, Ignots RA, et al. Comparison of tracheal and nasal chondrocytes for tissue engineering of the trachea. Ann Thorac Surg 2003; 76:1884-1888.
  • 6. Homicz MR, Chia SH, Schumacher BL, et al. Human septal chondrocyte redifferentiation in alginate, polyglycolic acid scaffold, and monolayer culture Laryngoscope 2003; 113: 25-32.
  • 7. Mayne R, Vail VS, Mayne PM, et al. Changes in type of collagen synthesized as clones of chic chondrocytes grow and eventually lose division capacity. Proc Natl Acad Sci USA 1976; 73: 1674-1978.
  • 8. Pittenger MF, Mackay Am, Beck SC, et al. Multilineage potential of adult human mesencyhmal stem cells. Science 1999; 284: 143-147.
  • 9. Dennis JE, Caplan Al. Differentiation potential of conditionally immortalized mesenchymal progenitor cells from adult marrow of a H-2Kb-tsA58 transgenic mouse. J Cell Physiol 1996; 167: 523-538.
  • 10. Warnke PH, Springer IN, Wiltfang J, et al. Growth and transplantation of a custom vascularised bone graft in a man. Lancet 2004; 364: 766-770.
  • 11. Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos AG, Langer R Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res 1993; 27: 11-23.
  • 12. Rotter N, Aigner J, Naumann A, Planck H, Hammer C, Burmester G, Sittinger M. Cartilage reconstruction in head and neck surgery: comparison of resorbable polymer scaffolds for tissue engineering of human septal cartilage. J Biomed Mater Res 1998; 5; 42:347-356.
  • 13. http://www.msm.cam.ac.uk/ccmm/projects/vam27.html. 14. Kamil SH, Vacanti MP, Paige KT, et al. Tissue engineering of a human sized and shaped auricle using a mold. Laryngoscope 2004; 114: 867-870.
  • 15. Burdick JA, Frankel D, Dernell WS, Anseth KS. An initial investigation of photocurable three-dimensional lactic acid based scaffolds in a critical-sized cranial defect. Biomaterials 2003; 24: 1613-1620.
  • 16. Hedberg EL, Kroese-Deutman HC, Shih CK, et al. Bone regenerative effect of varied release kinetics of the osteogenic thrombin peptide TP508 from biodegradable, polymeric scaffolds. J Biomed Mater Res, in press.
  • 17. Rice MA, Anseth KS. Encapsulating chondrocytes in copolymer gels: bimodal degradation kinetics influence cell phenotype and extracellular matrix development. J Biomed Mater Res A 2004; 15; 70:560-568.
  • 18. Bryant SJ, Anseth KS. Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J Biomed Mater Res A 2003; 1; 64: 70-79.
  • 19. Nussembaum B, Teknos Tn, Chepeha DB. Tissue engineering: The current status of this futuristic modality in head neck reconstruction. Curr P Opin Otolaryngol Head Neck Surgery 2004; 3212: 311-315.
  • 20. Gerstner AO, Tarnok A, Bootz F. [Slide-based multiparametric cytometry in ENT. Perspectives for the clinic and research]. HNO 2005; 53: 134-141.
  • 21. Rickert D, Lendlein A, Kelch S, et al. [Cell proliferation and cellular activity of primary cell cultures of the oral cavity after cell seeding on the surface of a degradable, thermoplastic block copolymer]. Biomed Tech (Berl) 2005; 50: 92-99.
  • 22. Brent B. Auricular repair with autogenous rib cartilage grafts: two decades of experience with 600 cases. Plast Reconstr Surg 1992; 90: 355-374; discussion 375-376.
  • 23. Walton RL, Beahm EK. Auricular reconstruction for microtia: Part II. Surgical techniques. Plast Reconstr Surg 2002; 110: 234-249; quiz 250-251, 387.
  • 24. Cao YL, Vacanti JP, Paige KT et al. Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast Reconstr Surg 1997; 100: 297-302.
  • 25. Rodriguez A, Cao YL, Ibarra C, Pap S, et al. Characteristics of cartilage engineered from human pediatric auricular cartilage. Plast Reconstr Surg 1999; 103:1111-1119.
  • 26. Megerian CA, Weitzner BD, Dore B, Bonassar LJ. Minimally invasive technique of auricular cartilage harvest for tissue engineering. Tissue Eng 2000;6: 69-74.
  • 27. Hertegard S Dahlqvist A, Laurent C, et al. A. Viscoelastic properties of rabbit vocal folds after augmentation. Otolaryngol Head Neac Surg 2003; 128: 401-406.
  • 28. de Jong AL, Park AH, Raveh E, et al. Comparison of thyroid, auricular, and costal cartilage donor sites for laryngotracheal reconstruction in an animal model. Arch Otolaryngol Head Neck Surg 2000;126: 49-53.
  • 29. Kojima K, Bonassar LJ, Roy AK, et al. A composite tissue-engineered trachea using sheep nasal chondrocyte and epithelial cells. FASEB J 2003; 17: 823-828.
  • 30. Okumus A, Cizmeci O, Kabakas F, et al. Circumferential trachea reconstruction with a prefabricated axial bio-synthetic flap: experimental study. Int J Pediatr Otorhinolaryngol 2005; 69: 335-344.
  • 31. Schimming R, Schmelzeisen R. Tissue-engineered bone for maxillary sinus augmentation. J Oral Maxillofac Surg 2004; 62: 724-729.
  • 32. Kohn FE, Feijen J, Feenstra L New perspectives in myringoplasty. Int J Artif Organs 1984; 7: 151-162.
  • 33. Feenstra L, van der Ven BW, Kohn FE, Feijen J. Experimental myringoplasty. Int J Artif Organs 1980;3: 354-357.
  • 34. Bucheler M, Haisch A. Tissue engineering in otorhinolaryngology. DNA Cell Biol 2003; 22: 549-564.
  • 35. Mizuno H, Hata K, Kojima K, et al. A novel approach to regenerating periodontal tissue by grafting autologous cultured periosteum. Tissue Eng 2006;12: 1227-1335.
  • 36. Nussenbaum B, Krebsbach PH. The role of gene therapy for craniofacial and dental tissue engineering. Adv Drug Deliv Rev 2006; Jun 9; [Epub ahead of print].
  • 37. Allen KD, Athanasiou KA. Tissue Engineering of the TMJ Disc: A Review. Tissue Eng 2006; 12: 1183-1196.
  • 38. Fissell WH, Manley S, Westover A, et al. Differentiated growth of human renal tubule cells on thin-film and nanostructured materials. ASAIO J 2006; 52: 221-227.
  • 39. Atala A. Recent applications of regenerative medicine to urologic structures and related tissues. Curr Opin Urol 2006; 16: 305-309.
  • 40. Frimberger D, Morales N, Gearhart JD, et al. Human embryoid body-derived stem cells in tissue engineering-enhanced migration in co-culture with bladder smooth muscle and urothelium. Urology 2006; 67:1298- 1303.
  • 41. Zorlutuna P, Tezcaner A, Kiyat I, et al. Cornea engineering on polyester carriers. J Biomed Mater Res A 2006; Jun 6; [Epub ahead of print].
  • 42. Bin F, Yinglong L, Nin X, et al. Construction of tissueengineered homograft bioprosthetic heart valves in vitro 2006; 52: 303-309.
  • 43. Sodian R, Lueders C, Kraemer L, et al. Tissue engineering of autologous human heart valves using cryopreserved vascular umbilical cord cells. Ann Thorac Surg 2006; 81: 2207-2216.
  • 44. Chiari C, Koller U, Dorotka R, et al. A tissue engineering approach to meniscus regeneration in a sheep model. Osteoarthritis Cartilage 2006; May 26; [Epub ahead of print].