Atrial Fibrilasyon İle ACE Gen Polimorfizmi Arasındaki İlişkinin İncelenmesi

Giriş ve Amaç: Atriyal fibrilasyon (AF) kardiyovasküler kaynaklı ritim bozuklukları içinde en sık görülenidir. Renin angiotensin sistemi (RAS)’nin AF patofizyolojisinde önemli bir role sahip olduğu ileri sürülmektedir. Yapılan çalışmalarda, ACE gen polimorfizmi ile AF arasında bir ilişki olduğu belirtilmiştir. Bu çalışmada, bizim toplumumuzda ACE gen polimorfizmi ile AF arasındaki ilişkiyi inceledik. Gereç ve Yöntemler: Bu polimorfizmin analizi 97 hasta ve 83 sağlıklı kontrolde gerçekleştirildi. Bu analiz için Polimeraz zincir reaksiyonu ve kısıtlayıcı enzim kesimi kullanıldı. Bulgular: Hasta ve kontrol grubunda ACE II, ID ve DD genotip dağılımları sırasıyla, II: % 17.5, ID: %42.3, DD: %40.2; II: % 27.7, ID: % 48.2, DD: %24.1 olarak bulunmuştur. ACE I ve D alel frekansları ise hasta grubunda I: 0.386, D: 0.614 iken kontrol grubunda I: 0.518, D: 0.482 olarak tespit edilmiş olup hasta ve kontrol grupları arasında anlamlı bir ilişki olduğu saptanmıştır (X2 = 5.98 ve p=0.050). Sonuç: Bu çalışmada, bizim toplumumuzda, ACE genindeki I/D polimorfizmi ile AF arasında istatiksel olarak anlamlı bir ilişki olduğu saptanmıştır

Anahtar Kelimeler:

Atriyal fibrilasyon, ACE, gen, polimorfizm

The Investigation Of Relationship Between Atrial Fibrillation And ACE Gene Polymorphism.

Objective: Atrial fibrillation (AF) is the most common cardiovascular arrhythmia. It has been suggested that the renin-angiotensin system (RAS) has an important role in the pathophysiology of AF. Studies have shown that there is a relationship between ACE gene polymorphism and AF. In this study, we examined the relationship between ACE gene polymorphism and AF in our population. Materials and Methods: We have examined this polymorphism in 97 patients and 83 controls. Polymerase chain reaction (PCR) and restriction fragment length polymorphism were used to analyse gene polymorphisms. Results: ACE II, ID and DD genotype distributions in the patient and control groups, respectively, were II: 17.5%, ID: 42.3%, DD: 40.2%; II: 27.7%, ID: 48.2%, DD: 24.1%. ACE I and D allele frequencies were determined as I: 0.386, D: 0.614 in the patient group, while I: 0.518, D: 0.482 in the control group, and a significant correlation was found between the patient and control groups (X2 = 5.98 and p=0.050). Conclusion: In this study, we found that the polymorphisms of ACE I/D gene polymorphism was associated with AF in our population.

Keywords:

Atrial fibrillation, ACE, gene, polymorphism.,

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