VİSSERAL ADİPOZİTE İNDEKSİ İLE KORONER ARTER HASTALIĞI ARASINDAKİ İLİŞKİ

Amaç: Koroner arter hastalığı (KAH) tüm dünyada morbidite ve mortalitenin önemli bir nedenidir. KAH riskiaçısından visseral adipozite, tek başına kilo fazlalığından daha değerli bir göstergedir. Biz bu çalışmada, tanıamaçlı elekti koroner anjiyograf yapılan hastalarda visseral adipozite indeksi (VAİ) ile KAH varlığı ve ciddiyet arasındaki ilişkiyi değerlendirmeyi amaçladık.Yöntem: Bu retrospekti çalışmada, kliniğimizde Ocak 2018 – Aralık 2018 tarihleri arasında tanısal koroneranjiyograf uygulanan 120 hastanın verileri kullanıldı. Koroner anjiyografier geriye dönük olarak incelendi.En az bir koroner arterinde %50 ve üzerinde darlığı olan hastalar KAH grubuna (n=75), belirgin koroner darlığı olmayan hastalar (n=45) kontrol grubuna alındı. Hastaların demografi özellikleri, boy, kilo, bel çevrelerive tetkik sonuçları kaydedildi. VAİ skorları kadın ve erkek hastalar için ayrı ayrı hesaplandı.Bulgular: Kontrol grubu ile karşılaştııldığında, açlık serum glukoz (p=0.025) ve VAİ (p = 0.014) KAH grubunda anlamlı olarak yüksek bulundu. KAH grubunda SYNTAX skoru, açlık glukoz (p = 0.011), trigliserid (p= 0.048) ve VAİ (p=0.003) ile poziti olarak korele idi. Çok değişkenli doğrusal regresyon analizinde, açlıkserum glukozu (p=0.012) ve VAİ (p =0.008) SYNTAX skorunun bağımsız prediktörü olarak tespit edildi.Sonuç: Koroner arter hastalığının takibinde değiştiilebilir risk faktörlerinin belirlenmesi ve yönetii çokönemlidir. Basit bir skorlama olan VAİ, KAH riskini belirlemek için kullanışlı bir yöntem olabilir.

The Relationship Between Visceral Adiposity Index And Coronary Artery Disease

Aim: Coronary artery disease (CAD) is an important cause of morbidity and mortality worldwide. In terms of CAD risk, visceral adiposity is a more valuable indicator than weight alone. In this study, we aimed to evaluate the relatin of visceral adiposity index (VAI) with the presence and severity of CAD in patints undergoing diagnosti coronary angiography. Methods: In this retrospectie study, data of 120 patints who underwent diagnosti coronary angiography between January 2018 and December 2018 were used. Coronary angiograms of the patints were evaluated retrospectiely. Patints with at least 50% stenosis in one or more coronary artery were included in the CAD group (n = 75) and patints without signifiant coronary stenosis (n = 45) were included in the control group. Demographic characteristis, height, weight, waist circumference and laboratory results were recorded. VAI scores were calculated separately for male and female patints. Results: Fastig serum glucose (p = 0.025) and VAI (p = 0.014) were signifiantly higher in CAD group when compared with control group. SYNTAX score was positiely correlated with fastig glucose (p = 0.011), triglyceride (p = 0.048) and VAI (p = 0.003) in the CAD group. In multiariate linear regression analysis, fastig serum glucose (p = 0.012) and VAI (p = 0.008) were determined as independent predictors of SYNTAX score. Conclusion: The determinatin and management of modifible risk factors is very important in the followup of patints with CAD. As a simple scoring method, VAI may be useful for determining the risk of CAD.

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1. Hennekens CH. Increasing burden of cardiovascular disease: current knowledge and future directins for research on risk factors. Circulatin. 1998;97(11):1095-102.
2. Lennon RP, Claussen KA, Kuersteiner KA. State of the Heart: An Overview of the Disease Burden of Cardiovascular Disease from an Epidemiologic Perspectie. Primary care. 2018;45(1):1-15.
3. Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obesity and cardiovascular disease: pathophysiology, evaluatin, and effct of weight loss. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(5):968-76.
4. Roberson LL, Aneni EC, Maziak W, Agatston A, Feldman T, Rousef M, et al. Beyond BMI: The "Metabolically healthy obese" phenotype & its associatin with clinical/subclinical cardiovascular disease and all-cause mortality -- a systemati review. BMC public health. 2014;14:14.
5. Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M, et al. Visceral Adiposity Index: a reliable indicator of visceral fat functin associated with cardiometabolic risk. Diabetes care. 2010;33(4):920-2.
6. Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroInterventin: journal of EuroPCR in collaboratin with the Working Group on Interventinal Cardiology of the European Society of Cardiology. 2005;1(2):219-27.
7. Davidson MH. Cardiovascular risk factors in a patint with diabetes mellitus and coronary artery disease: therapeuti approaches to improve outcomes: perspecties of a preventie cardiologist. The American journal of cardiology. 2012;110(9 Suppl):43b-9b.
8. Hanna-Moussa A, Gardner MJ, Kurukulasuriya LR, Sowers JR. Dysglycemia/prediabetes and cardiovascular risk factors. Reviews in cardiovascular medicine. 2009;10(4):202-8.
9. Schinner S, Futh R, Kempf K, Marti S, Willenberg HS, Schot M, et al. A progressive increase in cardiovascular risk assessed by coronary angiography in non-diabeti patints at sub-diabeti glucose levels. Cardiovascular diabetology. 2011;10:56.
10. Shimabukuro M, Kozuka C, Taira S, Yabiku K, Dagvasumberel M, Ishida M, et al. Ectopic fat depositin and global cardiometabolic risk: new paradigm in cardiovascular medicine. The journal of medical investiatin : JMI. 2013;60(1-2):1-14.
11. Han L, Fu KL, Zhao J, Wang ZH, Tang MX, Wang J, et al. Visceral adiposity index score indicated the severity of coronary heart disease in Chinese adults. Diabetology & metabolic syndrome. 2014;6(1):143.