EVALUATION OF THE SIMPLE HEMATOLOGIC MARKERS IN PATIENTS WITH GESTATIONAL DIABETES MELLITUS: A CASE-CONTROL STUDY Gestasyonel Diabetes Mellituslu Hastalarda Basit Hematolojik Belirteçlerin Değerlendirilmesi: Vaka-Kontrol Çalışması

ABSTRACT Objective: Gestational diabetes mellitus (GDM) is defined as various degrees of glucose intolerance that begins or is first detected during second or third trimester of pregnancy. In order to prevent serious maternal and/or neonatal outcomes, early diagnosis and adequate treatment strategies are of great importance. Simple hematologic parameters such as mean platelet volume (MPV), red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have increasingly been reported as measures of presence and severity of GDM. This study aimed to determine whether there is an association between these parameters and the presence of GDM Material and Methods: A total of 78 GDM patients and 89 age- and gestational-age-matched pregnant controls were studied. MPV, RDW, NLR and PLR values in all patients were calculated and recorded from complete blood cell counts. Results: For GDM patients, the mean MPV, NLR, PLR and RDW values were 8.8±1.0, 3.8±2.3, 120.6±42.9, and 15.3±2.6 respectively; for healthy pregnant controls, the values were 8.6±0.8, 3.5±2.1, 130.6±40.8, and 14.1±1.8 respectively. Although only MPV and RDW levels of GDM patients were significantly higher compared with healthy controls, no statistically significant difference was found between both study groups in respect to PLR and NLR. Conclusion: Mean platelet volume and RDW but not NLR and PLR, which are automatically calculated from complete blood count parameters plays important predictive roles in GDM. Keywords: Gestational Diabetes Mellitus; Mean Platelet Volume; Red Cell Distribution Width; Platelet-To-Lymphocyte Ratio; Neutrophil-To-Lymphocyte Ratio ÖZET Amaç: Gestasyonel Diabetes Mellitus (GDM) gebeliğin ikinci veya üçüncü trimesterinde başlayan veya tanı konan değişik derecedeki glukoz intoleransı olarak tanımlanır. Ciddi maternal ve/veya neonatal sonuçları önlemek için erken tanı ve uygun tedavi yaklaşımları büyük önem arz etmektedir. Ortalama platelet hacmi (MPV), kırmızı küre dağılım genişliği (RDW), nötrofil-lenfosit oranı (NLO) ve platelet –lenfosit oranı (PLO) gibi basit hematolojik parametrelerin GDM varlığı ve şiddetinin bir ölçütü olarak kullanılabileceği belirtilmiştir. Bu çalışmanın amacı bu parametreler ile GDM varlığı arasında bir ilişkinin var olup olmadığının belirlenmesidir. Gereç ve Yöntemler: Bu çalışmaya 78 GDM hastası ile gestasyonel yaş uyumlu 89 gebe kontrol dahil edilmiştir. MPV, RDW, NLO ve PLO değerleri tüm hastalar için tam kan sayımından hesaplanmış ve kaydedildi. Bulgular: GDM hastaları için ortalama MPV, NLO, PLO ve RDW değerleri sırasıyla 8,8±1,0, 3,8±2,3, 120,6±42,9 ve 15,3±2,6; kontrol grubu için ise sırasıyla 8,6±0,8, 3,5±2,1, 130,6±40,8 ve 14,1±1,8 idi. Her ne kadar MPV ve RDW değerleri GDM hastalarında kontrol grubu ile kıyaslandığında belirgin yüksek saptanmış ise de, NLO ve PLO değerleri her iki grupta benzer idi. Sonuç: Tam kan sayımından otomatik olarak hesaplanan MPV ve RDW değerlerinin GDM hastalarında yüksek olarak saptanması bu parametrelerin GDM’de prediktif rolleri olabileceğini düşündürtmektedir. Anahtar Kelimeler: Gestasyonel Diabetes Mellitus; Ortalama Trombosit Hacmi; Kırmızı Küre Dağılım Genişliği; Platelet –Lenfosit Oranı; Nötrofil-Lenfosit Oranı

THE QUADRATE TUBERCLE: A MORPHOMETRIC STUDY

ABSTRACT Objective Quadratus femoris muscle originates from ischial tuberosity and inserts into the quadrate tubercle of femur. Simply quadrate tubercle may be defined to be localized on the intertrochanteric crest. There are only a few more detailed descriptions of its localization. Consequently we have aimed to describe the exact localization of the quadrate tubercle. Material and Methods Morphometric measurements related with quadrate tubercle were performed on 144 adult human femurs. Afterwards proportional calculations between the measured morphometric measurements related with quadrate tubercle were made. Results Mean vertical distance between the most prominent points of greater and lesser trochanters was found as 63.13 mm. Mean vertical distance between the most prominent point of greater trochanter and origin of quadrate tubercle was measured as 21.78 mm. Mean vertical distance between the origin and end of quadrate tubercle was determined as 17.16 mm. Mean vertical distance between the end of quadrate tubercle and most prominent point of lesser trochanter was 24.26 mm. Mean length of femur was measured as 425.47 mm. Origin of quadrate tubercle was meanly found in the upper 35% of the distance between the most prominent points of greater and lesser trochanters and end of quadrate tubercle was meanly found to be located in the upper 62% of the same distance. Conclusion As location of quadrate tubercle hasn’t been discussed in detail yet, we believe that this study will be instructive for further anatomical or clinical studies related with it.

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Bozok Tıp Dergisi-Cover
  • ISSN: 2146-4006
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2015
  • Yayıncı: Bozok Üniversitesi
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