Clinical Outcomes of Radioactive Iodine Therapy in a Patient with Myasthenia Gravis and Hyperthyroidism
Clinical Outcomes of Radioactive Iodine Therapy in a Patient with Myasthenia Gravis and Hyperthyroidism
Myasthenia Gravis is an autoimmune disease characterized with muscle weakness and fatigue. Hyperthyroidism can be present with Myasthenia Gravis with a rate of 2-17.5 %. It is known that hyperthyroidism affects the clinical course of myasthenia gravis. A 27 years old woman with myasthenia gravis and recently occurred hyperthyroidism is presented in this study. Radioactive iodine therapy was applied to the patient and after 3 months of medication the patient become euthyroid and clinical findings of myasthenia were regressed.
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- 1. Drachman DB. Myasthenia gravis. N Engl J Med 1994;330:1797-810.
- 2. Ratanakorn D, Vejjajiva A. Long-term follow-up of myasthenia gravis patients with hyperthyroidism. Acta Neurol Scand 2002;106(2):93-8.
- 3. Marinó M, Ricciardi R, Pinchera A, Barbesino G, Manetti L, Chiovato L, Braverman LE, Rossi B, Muratorio A, Mariotti S.Mild clinical expression of myasthenia gravis associated with autoimmune thyroid diseases. J Clin Endocrinol Metab 1997; 82(2):438-43.
- 4. Datt V, Tempe DK, Singh B, Tomar AS, Banerjee A, Dutta D, Bhandari H.Anesthetic management of patient with myasthenia gravis and uncontrolled hyperthyroidism for thymectomy. Ann Card Anaesth 2010;13(1):49-52.
- 5. Trabelsi L, Charfi N, Triki Ch, Mnif M, Rekik N, Mhiri Ch, Abid M. Myasthenia gravis and hyperthyroidism: two cases. Ann Endocrinol (Paris) 2006;67(3):265-9.
- 6. Moura-Neto A, Mosci C, Santos AO, Amorim BJ, de Lima MC, Etchebehere EC, Tambascia MA, Ramos CD, Zantut-Wittmann DE . Predictive factors of failure in a fixed 15 mCi 131I-iodide therapy for Graves disease. Clin Nucl Med 2012;37(6):550-4.
- 7. Freedman S.Antisemitism and the history of myasthenia gravis. Isr Med Assoc J 2010;12(4):195-8
- 8. Waller E.E, Razavi M, Picchi J. Myasthenia Gravis and HyperthyroidismA Report of Two Cases Calif Med 1963;99(5): 3403.
- 9. Weetman Ap. Graves Dis. N Engl J Med 2000;343: 123648.
- 10. Knapska-Kucharska M, Oszukowska L, Lewiński A. Analysis of demographic and clinical factors affecting the outcome of radioiodine therapy in patients with hyperthyroidism Arch Med Sci 2010;6(4):611-6.